醉茄素 A
- CAS号:5119-48-2
- 英文名:WITHAFERIN A
- 中文名:醉茄素 A
- CBNumber:CB9454365
- 分子式:C28H38O6
- 分子量:470.6
- MOL File:5119-48-2.mol
- 熔点 :252-253℃
- 比旋光度 :D28 +125° (c = 1.30 in CHCl3)
- 沸点 :680.7±55.0 °C(Predicted)
- 密度 :1.28
- 闪点 :226℃
- 储存条件 :Desiccate at -20°C
- 溶解度 :Soluble in DMSO (up to 20 mg/ml)
- 酸度系数(pKa) :13.49±0.70(Predicted)
- 形态 :White solid
- 颜色 :White
- 稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChIKey :DBRXOUCRJQVYJQ-CKNDUULBSA-N
- 危险品标志 :T
- WGK Germany :3
- RTECS号 :KE7288500
- 海关编码 :29322090
醉茄素 A性质、用途与生产工艺
- 生物活性 Withaferin A (WA, WFA)可通过对硫代烷基化敏感的氧化还原机制阻止肿瘤坏死因子诱导的IκB激酶β的激活，从而有效地抑制 NF-κB 激活。Withaferin A 可与中间丝状体蛋白(IF) vimentin 结合，并具有抗肿瘤和抗血管生成活性。Withaferin A 是一种从 Withania somnifera 分离的甾体内酯。
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靶点
Target Value NF-κB
()vimentin
() -
体外研究
Withaferin A has antiinflammatory activity, and potently inhibits NF-kB activation by preventing the TNF-induced activation of Ik-B kinase beta via a thioalkylation-sensitive redox mechanism. Withaferin A also has anticancer activity. Withaferin A targets the IF protein vimentin, causes aggregation of vimentin filaments in bovine aortic endothelial cells (BAECs) at 3 μM, and induces vimentin fragmentation in endothelial cells at 10 μM. Withaferin A (0.5, 1.5 μM) alone or incombination with cisplatin (CIS) dose-dependently reduces tumorigenic potential of ALDH1 positive cancer stem cells (CSCs).
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体内研究
Withaferin A (2 mg/kg, i.p.) shows potent angiogenesis inhibitory activity via vimentin in mice. Withaferin A (2 mg/kg) combined with cisplatin (CIS) regulates the expression of ALDH1 marker, and downregulates the expression of securin in tumors collected from mice.
- 更新日期：2024/11/08
- 产品编号：S8587
- 产品名称：醉茄素 A Withaferin A
- CAS编号：5119-48-2
- 包装：1mg
- 价格：1470.11元
- 更新日期：2024/11/08
- 产品编号：S8587
- 产品名称：醉茄素 A Withaferin A
- CAS编号：5119-48-2
- 包装：5mg
- 价格：4290.34元
- 公司名称：n'TOX
- 联系电话：--
- 电子邮件：info@ntox.fr
- 国家：法国
- 产品数：263
- 优势度：0
