ChemicalBook CAS数据库列表 CP466722
CP466722
- CAS号:1080622-86-1
- 英文名:CP466722
- 中文名:CP466722
- CBNumber:CB92535567
- 分子式:C17H15N7O2
- 分子量:349.35
- MOL File:1080622-86-1.mol
CP466722化学性质
- 沸点 :642.3±65.0 °C(Predicted)
- 密度 :1.48
- 储存条件 :Keep in dark place,Sealed in dry,2-8°C
- 溶解度 :DMSO: soluble0.5mg/mL, clear (warmed)
- 酸度系数(pKa) :0.00±0.19(Predicted)
- 形态 :powder
- 颜色 :white to beige
安全信息
CP466722性质、用途与生产工艺
- 生物活性 CP-466722是一种有效的，可逆的ATM抑制剂，不影响ATR，且抑制PI3K或PIKK家族成员。
- 体外研究 In vitro, CP-466722 is identified as a potential inhibitor to decrease the activity of purified ATM kinase to phosphorylate GST-p53(1–101) substrate. In addition, CP-466722 also shows the inhibitory activities against abl and src kinases. In HeLa cells, CP-466722 at doses of 6μM, results in the inhibition in ATM-dependent phosphorylation by reversibly inhibiting ionizing radiation (IR)-induced ATM kinase activity. Besides, ATM-dependent p53 induction is also inhibited by CP-466722 in MCF-7 human breast cancer cells and primary and immortalized diploid human fibroblasts. In response to IR, CP-466722 increased proportion of cells with G2/M DNA content and reduces proportion of cells with G1-phase DNA content in HeLa cells. Transient exposure to CP-466722 for a period of 4 hours sensitizes HeLa cells to IR without affecting cell plating nor cell viability.
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靶点
ATM
4.1 μM (IC 50 )
CP466722上下游产品信息
上游原料
下游产品
CP466722 试剂级价格
- 更新日期：2025/02/08
- 产品编号：HY-11002
- 产品名称：CP466722 CP-466722
- CAS编号：1080622-86-1
- 包装：5mg
- 价格：800元
- 更新日期：2025/02/08
- 产品编号：HY-11002
- 产品名称：CP466722 CP-466722
- CAS编号：1080622-86-1
- 包装：10mg
- 价格：1400元
CP466722生产厂家
- 公司名称：Alsachim SAS
- 联系电话：--
- 电子邮件：sales@alsachim.com
- 国家：法国
- 产品数：424
- 优势度：0
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