2,3-二巯基丁二酸

简介生物活性体内研究 2,3-二巯基丁二酸试剂级价格

2,3-二巯基丁二酸

CAS号:304-55-2
英文名:Succimer
中文名:2,3-二巯基丁二酸
CBNumber:CB9142563
分子式:C4H6O4S2
分子量:182.22
MOL File:304-55-2.mol

2,3-二巯基丁二酸化学性质

熔点 :196-198 °C (dec.)(lit.)
沸点 :285.62°C (rough estimate)
密度 :1.439 (estimate)
折射率 :1.5220 (estimate)
储存条件 :-20°C
溶解度 :DMSO (Sparingly), Methanol (Slightly, Heated)
酸度系数(pKa) :pK1:2.71;pK2:3.48;pK3:8.89(SH);pK4:10.79(SH) (25°C)
形态 :Powder
颜色 :White to off-white
水溶解性 :Soluble in water, and ethanol (25 mg/ml, results in colorless to light yellow, clear).
Merck :14,8865
BRN :1725150
稳定性 :Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey :ACTRVOBWPAIOHC-XIXRPRMCSA-N
CAS 数据库 :304-55-2(CAS DataBase Reference)
EPA化学物质信息 :Butanedioic acid, 2,3-dimercapto-, (2R,3S)-rel- (304-55-2)

安全信息

危险品标志 :Xi
危险类别码 :36/37/38
安全说明 :24/25-36-26
WGK Germany :2
RTECS号 :WM7650000
F :10-23
TSCA :Yes
海关编码 :29309090
毒害物质数据 :304-55-2(Hazardous Substances Data)
毒性 :LD50 i.p. in mice: >3000 mg/kg (Friedheim, Corvi)

2,3-二巯基丁二酸化学药品说明书

二巯丁二酸|药典2005版
二巯丁二酸胶囊—二巯丁二酸的测定—沉淀滴定法|药物分析方法信息

2,3-二巯基丁二酸性质、用途与生产工艺

简介 2,3-二巯基丁二酸（英文缩写为：DMSA），别名2,3-二巯基琥珀酸，是一种有机硫化合物，常温下为白色结晶状粉末。因分子内含有两个巯基，所以它带有巯基化合物特有的臭味。二巯基丁二酸和它的钠盐都可以作为解毒剂通过口服或注射治疗重金属中毒。二巯基丁二酸有两种非对映异构体，一种是内消旋体，另一种是外消旋体。内消旋体可作为螯合剂使用，常用其钠盐。
生物活性 Succimer (Dimercaptosuccinic acid) 是一种广泛用于研究铅中毒的螯合剂。
体内研究

Succimer is a widely used chelating agent for the treatment of Pb poisoning. Red blood cells (RBCs) from lead exposed animals treated with NAC or Succimer are shown to have significantly higher glutathione (GSH) levels and diminished malondialdehyde (MDA) levels when compare to the lead group. Succimer administration also results in decreased glucose 6-phosphate dehydrogenase (G6PD) activity in RBCs from lead exposed animals. Succimer treatment produces a significant reduction in blood lead levels for both lead exposure conditions: the High Pb-succ group has blood lead levels that are 27% of the blood lead levels of the High Pb group at the end of treatment. Succimer is effective in substantially reducing brain lead, as brain lead levels in the High Pb-succ group are 37% of levels in the High Pb group.
化学性质白色结晶性粉末。熔点196-198℃（分解）。易溶于碱溶液，微溶于甲醇，不溶于水。具有巯基化合物的特臭，在空气中逐渐氧化。
用途该品是解毒药二巯基丁二酸钠的中间体。
用途一种镉的选择性掩蔽剂，用于锌的EDTA滴定
用途用作重金属解毒药、保健药
生产方法由二溴丁二酸经消除、加成、水解而得。