(+)-氯前列烯醇

(+)-氯前列烯醇化学性质

沸点 :628.0±55.0 °C(Predicted)
密度 :1.321
储存条件 :Store at -20°C
溶解度 :DMF: >100 mg/ml (from Fluprostenol); DMSO: >100 mg/ml (from Fluprostenol; Ethanol: >100 mg/ml (from Fluprostenol); PBS pH 7.2: >16 mg/ml (from Fluprostenol)
酸度系数(pKa) :4.76±0.10(Predicted)
形态 :Oil
颜色 :Colorless to light yellow

(+)-氯前列烯醇性质、用途与生产工艺

生物活性 (+)-Cloprostenol 是前列腺素 F2α 的类似物，为选择性的 prostaglandin receptor 激动剂。
靶点

PGF _2α
体外研究

D-Cloprostenol and PGF2 alpha are equipotent, about 150 times more potent than dl-cloprostenol (P < 0.05) and approximately 280 times more potent than PGE1 in inhibiting [ ³ H]PGF2 alpha binding to corpus luteum cell membranes. However, d-cloprostenol and PGF2 alpha are about 10 times more potent than dl-cloprostenol and approximately 95 times more potent than PGE1 in myometrial cell membranes.
体内研究

D-cloprostenol (15 g per head) is the lowest dose that consistently achieves abortion; D-cloprostenol causes mild adverse effects including salivation, defecation and hyperventilation in bitches weighing less than 10 kg. Intra-vesicle administration of a single low dose of d-cloprostenol is a safe and successful technique to induce abortion in the bitch.

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