依来多辛
- CAS号:69-25-0
- 英文名:Eledoisin
- 中文名:依来多辛
- CBNumber:CB8186874
- 分子式:C54H85N13O15S
- 分子量:1188.4
- MOL File:69-25-0.mol
- 熔点 :230 °C (decomp)
- 沸点 :1618.1±65.0 °C(Predicted)
- 密度 :1.289±0.06 g/cm3(Predicted)
- 储存条件 :−20°C
- 溶解度 :DMF: 15 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:20): 0.04 mg/ml
- 形态 :A crystalline solid
- 酸度系数(pKa) :4.19±0.10(Predicted)
- 颜色 :White to off-white
- 旋光性 (optical activity) :-4422 (95% Acetic Acid)
- WGK Germany :3
- RTECS号 :JX8688000
- 海关编码 :3504009000
依来多辛性质、用途与生产工艺
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用途
依来多辛是 NK2 和 NK3 受体的特异性激动剂。
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靶点
NK2 and NK3 receptors.
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体外研究
Eledoisin (Eledone peptide) increases the value recorded under basal conditions by 24.5±3.7%; this stimulation is significantly (P<0.01) lowered to 13.1±1.9% by the simultaneous presence of CP99994. The same protocol is also used to characterize the sensitivity of Eledoisin stimulation to 0.1 μM SR48968 or 0.1 μM SB222200. SR48968 significantly (P < 0.01) lower the stimulation by Eledoisin, while SB222200 has no effect. Eledoisin stimulation is reduced by CP99994 and SR48968, NK1 and NK2 antagonists, respectively.
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体内研究
Eledoisin (Eledone peptide; 0.1-1 nmol/kg) injected into rats produces a biphasic cardiovascular response that consists of an initial fall of systemic blood pressure (8-15 mm Hg) followed by a rise (20-22 mm Hg). Intracerebroventricular injection of Eledoisin produces an enhancement of grooming and scratching behavior in mice.
- 更新日期：2024/11/08
- 产品编号：HY-P0006
- 产品名称：依来多辛 Eledoisin
- CAS编号：69-25-0
- 包装：5mg
- 价格：900元
- 更新日期：2024/11/08
- 产品编号：HY-P0006
- 产品名称：依来多辛 Eledoisin
- CAS编号：69-25-0
- 包装：10mg
- 价格：1440元
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
