L-硒代蛋氨酸
- CAS号:3211-76-5
- 英文名:L-Selenomethionine
- 中文名:L-硒代蛋氨酸
- CBNumber:CB8183929
- 分子式:C5H11NO2Se
- 分子量:196.11
- MOL File:3211-76-5.mol
- 熔点 :265 °C
- 比旋光度 :18 º (c=1, 1N HCl)
- 沸点 :320.8±37.0 °C(Predicted)
- 折射率 :18 ° (C=0.5, 2mol/L HCl)
- 储存条件 :-20°C
- 溶解度 :H2O: 50 mg/mL
- 形态 :powder
- 酸度系数(pKa) :2.26±0.10(Predicted)
- 颜色 :white to off-white
- 水溶解性 :soluble
- Merck :14,8441
- InChI :InChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
- InChIKey :RJFAYQIBOAGBLC-BYPYZUCNSA-N
- SMILES :C(O)(=O)[C@@H](N)CC[Se]C
- LogP :0.152 (est)
- CAS 数据库 :3211-76-5(CAS DataBase Reference)
- 危险品标志 :T,N
- 危险类别码 :23/25-33-50/53
- 安全说明 :20/21-28-45-60-61-28A
- 危险品运输编号 :UN 3283 6.1/PG 2
- WGK Germany :3
- RTECS号 :EK7713840
- F :10
- 危险等级 :6.1
- 包装类别 :III
- 海关编码 :29309090
L-硒代蛋氨酸 MSDS
L-(+)-Selenomethionine
L-硒代蛋氨酸性质、用途与生产工艺
- 生物活性 L-SelenoMethionine 是 Selenomethionine 的 L-异构体，是硒的主要天然食物形式。L-SelenoMethionine 是一种癌症化学预防剂，可以通过饮食补充降低癌症的发生率并诱导癌细胞凋亡。L-SelenoMethionine 还可以增加谷胱甘肽过氧化物酶的表达。
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靶点
Human Endogenous Metabolite
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体外研究
L-SelenoMethionine (1-500 μM; 24-72 h) is selectively inhibits the growth of prostate cancer cells, compared with normal cells.
L-SelenoMethionine (500 μM; 48 h) induce apoptosis in prostate cancer cells.
L-SelenoMethionine (500 μM; 48 h) causes an increase in arrest in the G2-M phase of the cell cycle selectively in prostate cancer cells.
L-SelenoMethionine (5 μM; 24 h) mitigates gene expression associated with the cellular stress response from 10 cGy irradiation.
Cell Viability Assay
Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt) Concentration: 1, 5, 10, 50, 100, 500 μM Incubation Time: 24, 48, 72 hours Result: Inhibited the growth of prostate cancer cells, with a lower IC 50 (1-90 μM) at 72 h than normal prostate cells (>500 μM). Apoptosis Analysis
Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt) Concentration: 500 μM Incubation Time: 48 hours Result: Exhibited the highest level of DNA condensation in androgen-responsive LNCaP carcinoma cells, followed by PC-3 and DU145 cells.
Exhibited the nicked-end DNA labeling in prostate cancer cells.
Promoted the PARP cleavage in prostate cancer cells.Cell Cycle Analysis
Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt) Concentration: 500 μM Incubation Time: 48 hours Result: Increased the sub-G0-G1 cell fraction of LNCaP (41.5%), PC-3 (12.1%), and DU145 cells (11.2%).
Caused a significant increases in G2 cells , particularly in LNCaP (13%), PC-3 (32%), and DU145 (20%) cells.RT-PCR
Cell Line: Human thyroid epithelial cells (HTori-3) Concentration: 5 μM Incubation Time: 24 hours Result: Downregulated the CDC6, GADD45A, FAS and ATF3 in irradiated cells. -
体内研究
L-SelenoMethionine (0.06-12 μg/g diet; p.o. for 3 d) partially or completely prevent the decrease in the serum or plasma levels of total antioxidants in rats exposed to gamma rays, protons or HZE particles.
- 用途 可以用于蛋白质的结构分析。拿此产品来饲养细菌，这样最终形成的蛋白质里的特定位置就会被硒所取代，便于结构测定
- 更新日期：2024/11/11
- 产品编号：XW321176502
- 产品名称：L-硒代蛋氨酸
- CAS编号：3211-76-5
- 包装：250MG
- 价格：120元
- 更新日期：2024/11/11
- 产品编号：XW321176501
- 产品名称：L-硒代蛋氨酸
- CAS编号：3211-76-5
- 包装：1G
- 价格：230元
- 公司名称：TOKYO CHEMICAL INDUSTRY CO., LTD.
- 联系电话：03-36680489
- 电子邮件：Sales-JP@TCIchemicals.com
- 国家：日本
- 产品数：28387
- 优势度：80
- 公司名称：NACALAI
- 联系电话：--
- 电子邮件：info-tech@nacalai.co.jp
- 国家：日本
- 产品数：6046
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- 公司名称：KANTO
- 联系电话：--
- 电子邮件：reag-info@gms.kanto.co.jp
- 国家：日本
- 产品数：6756
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- 公司名称：WAKO
- 联系电话：--
- 电子邮件：labchem-tec@wako-chem.co.jp
- 国家：日本
- 产品数：6819
- 优势度：80
