紫铆因
- CAS号:487-52-5
- 英文名:BUTEIN
- 中文名:紫铆因
- CBNumber:CB8136455
- 分子式:C15H12O5
- 分子量:272.25
- MOL File:487-52-5.mol
- 熔点 :216°C
- 沸点 :560.9±50.0 °C(Predicted)
- 密度 :1.483±0.06 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :DMSO: >50 mg/mL
- 形态 :solid
- 酸度系数(pKa) :7.44±0.35(Predicted)
- 颜色 :yellow
- LogP :2.405 (est)
- CAS 数据库 :487-52-5(CAS DataBase Reference)
- 安全说明 :22-24/25
- WGK Germany :3
- 海关编码 :29145090
紫铆因性质、用途与生产工艺
- 生物活性 Butein，可从 Dalbergia odorifera T. Chen 分离，是一种 cAMP 特异性的 PDE 抑制剂，对 PDE4 的 IC50为 10.4 μM。Butein 是蛋白酪氨酸激酶抑制剂，对 EGFR 和 p60c-src 的 IC50 分别为 16 和 65 μM。Butein 通过 AKT 和 ERK/p38 MAPK 通路，靶向 FoxO3a 使 HeLa 细胞对 Cisplatin 敏感。Butein 还是一种 SIRT1 激活剂 (STAC)。
-
靶点
EGFR
16 μM (IC 50 , in HepG2 cells)
PDE4
10.4 μM (IC 50 )
-
体外研究
Butein potently inhibits cAMP-specific phosphodiesterase (type IV) activity with an IC 50 of 10.4±0.4 μM. In contrast, phosphodiesterase I, III and V activities were inhibited by Butein above 100 μM.
Butein, a plant polyphenol, is a specific protein tyrosine kinase inhibitor. Butein inhibits not only the EGF-stimulated auto-phosphotyrosine level of EGFR in HepG2 cells but also tyrosine-specific protein kinase activities of EGFR (IC 50 =16 μM) and p60 c-src (IC 50 =65 μM) in vitro.
Butein (10, 20, and 40 μM; 24, 48, and 72 hours) inhibits cell growth in a dose- and time-dependent manner.
Butein exhibits anticancer activity through the inhibition of the activation of PKB/AKT and MAPK pathways, which are two pathways known to be involved in resistance to cisplatin. Butein (20 µM) decreases phosphorylation of AKT, ERK and p38 following 24 h of co-treatment with Cisplatin (20 µM).Cell Viability Assay
Cell Line: HeLa cells Concentration: 10, 20, and 40 μM Incubation Time: 24, 48, and 72 hours Result: Inhibited cell growth in a dose- and time-dependent manner. Western Blot Analysis
Cell Line: HeLa cells Concentration: 20 µM Incubation Time: 24 hours Result: Decreased phosphorylation of AKT, ERK and p38 co-treatment with Cisplatin (20 µM). -
体内研究
Butein (2 mg/kg every 2 days) in combination with Cisplatin (2 mg/kg every 2 days) for 3 weeks suppresses tumor growth in vivo.
Animal Model: Nude mice (12 female 6- or 7-week old) with subcutaneous tumor xenografts Dosage: 2 mg/kg Administration: Intraperitoneally; every 2 days; for 3 weeks Result: Enhanced the antitumor effects of Cisplatin in vivo. -
用途
Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-κB in activated human mast cells: suppression of tumor necrosis factor-α, interleukin (IL)-6, and IL-8. Anti-inflammatory agent
- 更新日期：2024/11/08
- 产品编号：B3803
- 产品名称：紫铆因 Butein
- CAS编号：487-52-5
- 包装：100mg
- 价格：610元
- 更新日期：2024/11/08
- 产品编号：B3803
- 产品名称：紫铆因 Butein
- CAS编号：487-52-5
- 包装：1g
- 价格：2990元
- 公司名称：TCI Europe
- 联系电话：320-37350700
- 电子邮件：sales@tcieurope.eu
- 国家：欧洲
- 产品数：23671
- 优势度：75
