紫铆因 性质
| 熔点 | 216°C |
|---|---|
| 沸点 | 560.9±50.0 °C(Predicted) |
| 密度 | 1.483±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：>50 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 7.44±0.35(Predicted) |
| 颜色 | 粘黄色 |
| LogP | 2.405 (est) |
| CAS 数据库 | 487-52-5(CAS DataBase Reference) |
紫铆因 用途与合成方法
|
EGFR 16 μM (IC 50 , in HepG2 cells) |
PDE4 10.4 μM (IC 50 ) |
Butein potently inhibits cAMP-specific phosphodiesterase (type IV) activity with an IC
50
of 10.4±0.4 μM. In contrast, phosphodiesterase I, III and V activities were inhibited by Butein above 100 μM.
Butein, a plant polyphenol, is a specific protein tyrosine kinase inhibitor. Butein inhibits not only the EGF-stimulated auto-phosphotyrosine level of EGFR in HepG2 cells but also tyrosine-specific protein kinase activities of EGFR (IC
50
=16 μM) and p60
c-src
(IC
50
=65 μM) in vitro.
Butein (10, 20, and 40 μM; 24, 48, and 72 hours) inhibits cell growth in a dose- and time-dependent manner.
Butein exhibits anticancer activity through the inhibition of the activation of PKB/AKT and MAPK pathways, which are two pathways known to be involved in resistance to cisplatin. Butein (20 µM) decreases phosphorylation of AKT, ERK and p38 following 24 h of co-treatment with Cisplatin (20 µM).
Cell Viability Assay
| Cell Line: | HeLa cells |
| Concentration: | 10, 20, and 40 μM |
| Incubation Time: | 24, 48, and 72 hours |
| Result: | Inhibited cell growth in a dose- and time-dependent manner. |
Western Blot Analysis
| Cell Line: | HeLa cells |
| Concentration: | 20 µM |
| Incubation Time: | 24 hours |
| Result: | Decreased phosphorylation of AKT, ERK and p38 co-treatment with Cisplatin (20 µM). |
Butein (2 mg/kg every 2 days) in combination with Cisplatin (2 mg/kg every 2 days) for 3 weeks suppresses tumor growth in vivo.
| Animal Model: | Nude mice (12 female 6- or 7-week old) with subcutaneous tumor xenografts |
| Dosage: | 2 mg/kg |
| Administration: | Intraperitoneally; every 2 days; for 3 weeks |
| Result: | Enhanced the antitumor effects of Cisplatin in vivo. |
Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-κB in activated human mast cells: suppression of tumor necrosis factor-α, interleukin (IL)-6, and IL-8. Anti-inflammatory agent
紫铆因 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | B3803 | 紫铆因 | 487-52-5 | 100mg | 610 |
| 2024-11-08 | B3803 | 紫铆因 | 487-52-5 | 1g | 2990 |
