N-氧代烟酰胺
- CAS号:1986-81-8
- 英文名:Nicotinamide-N-oxide
- 中文名:N-氧代烟酰胺
- CBNumber:CB7664988
- 分子式:C6H6N2O2
- 分子量:138.12
- MOL File:1986-81-8.mol
- 熔点 :291-293 °C (dec.)(lit.)
- 沸点 :253.51°C (rough estimate)
- 密度 :1.3471 (rough estimate)
- 折射率 :1.5100 (estimate)
- 储存条件 :Inert atmosphere,Room Temperature
- 溶解度 :DMSO (Slightly, Heated), Methanol (Slightly, Heated)
- 形态 :Solid
- 酸度系数(pKa) :14.38±0.50(Predicted)
- 颜色 :White to Off-White
- 敏感性 :Hygroscopic
- CAS 数据库 :1986-81-8(CAS DataBase Reference)
N-氧代烟酰胺 MSDS
3-(Aminocarbonyl)pyridinium-1-olate
N-氧代烟酰胺性质、用途与生产工艺
- 生物活性 Nicotinamide N-oxide是生物体内烟酰胺分解代谢物, 是高效选择性的CXCR2受体拮抗剂。
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靶点
CXCR2
Human Endogenous Metabolite
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体外研究
Nicotinamide is one of the forms of vitamin B 3 . It is a precursor for nicotinamide adenine dinucleotide, which is best known as an electron carrier in oxidative phosphorylation and as a cofactor for many dehydrogenases. It is metabolized through two enzymatic systems. The first system starts with the methylation of nicotinamide by nicotinamide N-methyltransferase, which can subsequently be oxidized by aldehyde oxidase. The second enzymatic system oxidizes nicotinamide to nicotinamide N-oxide. A series of nicotinamide N-oxides is synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Compound 1 has demonstrated potent inhibition of neutrophil chemotaxis (IC 50 =10 nM). Compound 2 is a selective antagonist of IL-8 binding (IC 50 =110 nM) and potent inhibitor of neutrophil chemotaxis (IC 50 =170 nM).
- 用途 烟酰胺N-氧化物是烟酸类相关化合物,用于烟酸相关粒细胞分化的机制的研究 如人类早幼粒细胞性白血病细胞(HL-60)。烟酰胺N-氧化物减少对HL-60细胞株中c-myc的表达。
- 更新日期:2024/11/11
- 产品编号:XW19868183
- 产品名称:烟碱-N-氧化物 nicotinamide n-oxide;3-?pyridinecarboxamide;oxynicotinamide
- CAS编号:1986-81-8
- 包装:100G
- 价格:648元
- 更新日期:2024/11/11
- 产品编号:XW19868182
- 产品名称:烟碱-N-氧化物 nicotinamide n-oxide;3-?pyridinecarboxamide;oxynicotinamide
- CAS编号:1986-81-8
- 包装:25G
- 价格:184元
- 公司名称:SPECS
- 联系电话:--
- 电子邮件:info@specs.net
- 国家:荷兰
- 产品数:6833
- 优势度:70