生物活性 靶点 体外研究 N-氧代烟酰胺 试剂级价格
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N-氧代烟酰胺

N-氧代烟酰胺,1986-81-8,结构式
N-氧代烟酰胺
  • CAS号:1986-81-8
  • 英文名:Nicotinamide-N-oxide
  • 中文名:N-氧代烟酰胺
  • CBNumber:CB7664988
  • 分子式:C6H6N2O2
  • 分子量:138.12
  • MOL File:1986-81-8.mol
N-氧代烟酰胺化学性质
  • 熔点 :291-293 °C (dec.)(lit.)
  • 沸点 :253.51°C (rough estimate)
  • 密度 :1.3471 (rough estimate)
  • 折射率 :1.5100 (estimate)
  • 储存条件 :Inert atmosphere,Room Temperature
  • 溶解度 :DMSO (Slightly, Heated), Methanol (Slightly, Heated)
  • 形态 :Solid
  • 酸度系数(pKa) :14.38±0.50(Predicted)
  • 颜色 :White to Off-White
  • 敏感性 :Hygroscopic
  • CAS 数据库 :1986-81-8(CAS DataBase Reference)
安全信息
  • 危险品标志 :Xi
  • 危险类别码 :36/37/38
  • 安全说明 :26-36
  • WGK Germany :3
  • 海关编码 :29339900

N-氧代烟酰胺 MSDS


3-(Aminocarbonyl)pyridinium-1-olate

N-氧代烟酰胺性质、用途与生产工艺

  • 生物活性 Nicotinamide N-oxide是生物体内烟酰胺分解代谢物, 是高效选择性的CXCR2受体拮抗剂。
  • 靶点

    CXCR2

    Human Endogenous Metabolite

  • 体外研究

    Nicotinamide is one of the forms of vitamin B 3 . It is a precursor for nicotinamide adenine dinucleotide, which is best known as an electron carrier in oxidative phosphorylation and as a cofactor for many dehydrogenases. It is metabolized through two enzymatic systems. The first system starts with the methylation of nicotinamide by nicotinamide N-methyltransferase, which can subsequently be oxidized by aldehyde oxidase. The second enzymatic system oxidizes nicotinamide to nicotinamide N-oxide. A series of nicotinamide N-oxides is synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Compound 1 has demonstrated potent inhibition of neutrophil chemotaxis (IC 50 =10 nM). Compound 2 is a selective antagonist of IL-8 binding (IC 50 =110 nM) and potent inhibitor of neutrophil chemotaxis (IC 50 =170 nM).

  • 用途  烟酰胺N-氧化物是烟酸类相关化合物,用于烟酸相关粒细胞分化的机制的研究 如人类早幼粒细胞性白血病细胞(HL-60)。烟酰胺N-氧化物减少对HL-60细胞株中c-myc的表达。
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N-氧代烟酰胺 试剂级价格
  • 更新日期:2024/11/11
  • 产品编号:XW19868183
  • 产品名称:烟碱-N-氧化物 nicotinamide n-oxide;3-?pyridinecarboxamide;oxynicotinamide
  • CAS编号:1986-81-8
  • 包装:100G
  • 价格:648元
  • 更新日期:2024/11/11
  • 产品编号:XW19868182
  • 产品名称:烟碱-N-氧化物 nicotinamide n-oxide;3-?pyridinecarboxamide;oxynicotinamide
  • CAS编号:1986-81-8
  • 包装:25G
  • 价格:184元
N-氧代烟酰胺生产厂家
  • 公司名称:TCI AMERICA
  • 联系电话:800-4238616
  • 电子邮件:sales@tciamerica.com
  • 国家:美洲
  • 产品数:23653
  • 优势度:75
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