ChemicalBook CAS数据库列表 H-151
H-151
- CAS号:941987-60-6
- 英文名:1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
- 中文名:H-151
- CBNumber:CB74635441
- 分子式:C17H17N3O
- 分子量:279.34
- MOL File:941987-60-6.mol
H-151化学性质
- 沸点 :399.9±25.0 °C(Predicted)
- 密度 :1.298±0.06 g/cm3(Predicted)
- 储存条件 :Sealed in dry,Room Temperature
- 溶解度 :Soluble in DMSO (25 mg/ml)
- 形态 :solid
- 酸度系数(pKa) :14.96±0.70(Predicted)
- 颜色 :Off-white
- 稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
H-151性质、用途与生产工艺
- 生物活性 H-151是STING的共价拮抗剂，在人细胞和体内均具有显著的抑制活性。
-
靶点
Target Value STING
() -
体外研究
H-151 (0.02-2 μM) reduces IFNβ luciferase reporter measurements of HEK293T cells.
H-151 (0.5 μM; 2 h) inhibits the phosphorylation of TBK1 in THP-1 cells.
H-151 (1 μM; 3 h) suppresses hsSTING palmitoylation. -
体内研究
H-151 (750 nmol per mouse; a single i.p.) markedly reduces systemic cytokine responses in CMA-treated mice.
H-151 (750 nmol per mouse; i.p. daily for 7 d) exhibits notable efficacy in Trex1 −/− mice that expressed a bioluminescent IFNβ reporter.
H-151 (750 nmol per mouse; i.p.) reaches effective systemic levels, displays a short half-life in the serum and forms an adduct to mmSTING in wild-type mice.
H-151上下游产品信息
上游原料
下游产品
H-151 试剂级价格
- 更新日期：2024/11/08
- 产品编号：S6652
- 产品名称：H-151
- CAS编号：941987-60-6
- 包装：10mM (1mL in DMSO)
- 价格：958.23元
- 更新日期：2024/11/08
- 产品编号：HY-112693
- 产品名称：H-151 H-151
- CAS编号：941987-60-6
- 包装：5 mg
- 价格：800元
H-151生产厂家
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6100
- 优势度：58
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