金黄紫堇碱
- CAS号:6451-73-6
- 英文名:SCOULERIN
- 中文名:金黄紫堇碱
- CBNumber:CB7382903
- 分子式:C19H21NO4
- 分子量:327.37
- MOL File:6451-73-6.mol
- 熔点 :192°C
- 沸点 :503.3±50.0 °C(Predicted)
- 密度 :1.37±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in DMSO
- 形态 :A crystalline solid
- 酸度系数(pKa) :9.88±0.20(Predicted)
- 颜色 :Off-white to pink
金黄紫堇碱性质、用途与生产工艺
- 用途 金黄紫堇碱是完整的碳环。它不仅是提供原小檗碱类生物碱合成的基本骨架，也是许多生物碱合成的前体物质，例如小檗碱以及苯并菲啶类生物碱。
- 生物活性 Scoulerine ((-)-Scoulerine) 是一种有效的抗有丝分裂 (antimitotic) 化合物。Scoulerine 也是 BACE1 (淀粉样前体蛋白裂解酶 1) 的抑制剂。Scoulerine 抑制细胞增殖，阻止细胞周期，并诱导癌细胞凋亡。
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体外研究
Scoulerine ((-)-Scoulerine) inhibits mini-panel of human leukemic cells, MOLT-4 (WT), Jurkat (TP53 mutated), Raji (TP53 mutated), HL-60 (TP53 null), U-937 (TP53 mutated), and HEL 92.1.7 (wild-type), with IC 50 s ranging from 2.7 µM to 6.5 µM.
Scoulerine (2.5-20 µM; 24 hours) decreases proliferation of Jurkat and MOLT-4 cells.
Scoulerine (2.5-20 µM; 24 hours) induces MOLT-4 and Jurkat cells apoptosis.
Scoulerine induces G2 or M cell cycle arrest.
Scoulerine (2.5-5 µM; 24 hours) shows an upregulation of p53 protein in p53 wild-type MOLT-4 cells.
Scoulerine (2.5-5 µM; 24-48 hours) activates caspase-3/7, -8 and -9 in a dose-dependent manner.
Scoulerine (5-10 µM; 24 hours) disrupts microtubule structure of A549 lung carcinoma cellsCell Proliferation Assay
Cell Line: Jurkat and MOLT-4 cells Concentration: 2.5, 5, 10, 15 and 20 µM Incubation Time: 24 hours Result: Significantly reduced the viability and proliferation of Jurkat and MOLT-4 cells in a dose dependent manner. Apoptosis Analysis
Cell Line: MOLT-4 and Jurkat cells Concentration: 2.5, 5, 10, 15 and 20 µM Incubation Time: 24 hours Result: Induced MOLT-4 and Jurkat cells apoptosis. Cell Cycle Analysis
Cell Line: Jurkat and MOLT-4 leukemic cells Concentration: 2.5-20 µM Incubation Time: 16 hours Result: Induced cell cycle arrest at the G2/M transition. Western Blot Analysis
Cell Line: MOLT-4 cells Concentration: 2.5, 5 µM Incubation Time: 24 hours Result: Showed an upregulation of p53 protein in p53 wild-type MOLT-4 cells.
- 更新日期：2024/11/08
- 产品编号：HY-N1255
- 产品名称：金黄紫堇碱 Scoulerine
- CAS编号：6451-73-6
- 包装：1 mg
- 价格：550元
- 更新日期：2024/11/08
- 产品编号：HY-N1255
- 产品名称：金黄紫堇碱 Scoulerine
- CAS编号：6451-73-6
- 包装：5mg
- 价格：2000元
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6038
- 优势度：71
