松茋

用途生物活性体外研究松茋试剂级价格

松茋

CAS号:42438-89-1
英文名:Pinostilbene
中文名:松茋
CBNumber:CB72499191
分子式:C15H14O3
分子量:242.27
MOL File:42438-89-1.mol

松茋化学性质

熔点 :117-118℃
密度 :1.252
储存条件 :Keep in dark place,Inert atmosphere,2-8°C
溶解度 :DMSO: ≥13mg/mL
形态 :powder
颜色 :white to tan

安全信息

危险品标志 :Xi,N
危险类别码 :37/38-41-50
安全说明 :26-39-61
危险品运输编号 :UN 3077 9 / PGIII
WGK Germany :3
海关编码 :2909.50.5000

松茋性质、用途与生产工艺

用途松茋可用于含量测定，不作其他用途。
生物活性 Pinostilbene 是 Pterostilbene 的一种主要代谢物。Pinostilbene 对结肠癌细胞有抑制作用。

体外研究

Pinostilbene (0- 40 μM; 24 hours, 48 hours) does not cause significant inhibition on the growth of normal colon cells.
Pinostilbene (20 μM, 40 μM; 24 hours, 48 hours) causes a significant and dose-dependent increase in the percentage of cells in S phase in both HCT116 and HT29 cells compared to the control cells.
Pinostilbene at μM also induces a modest increase of cell population in G2/M phase in HT29 cells.
Pinostilbene(20 μM, 40 μM; 24 hours, 48 hours) modulates expression of key signaling proteins related to cell proliferation and apoptosis.
Pinostilbene also acts as a resveratrol methylated derivative and displays protective effects against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells.

Cell Viability Assay

Cell Line:	HCT116 cells, HT29 cells
Concentration:	24 hours, 48 hours
Incubation Time:	0-100 μM
Result:	Inhibited the growth of two human colon cancer cells.

Apoptosis Analysis

Cell Line:	HCT116 cells, HT29 cells
Concentration:	20 μM, 40 μM
Incubation Time:	24 hours, 48 hours
Result:	Caused a significant and dose-dependent increase in the percentage of cells in S phase.

Cell Viability Assay

Cell Line:	HCT116 cells
Concentration:	20 μM,40 μM
Incubation Time:	24 hours, 48 hours
Result:	Significantly increased the expression levels of p53, Bax, cleaved caspase-3, cleaved PARP and p21 ^Cip1/Waf1 , while decreased the expression levels of cyclin E and p-Rb.