生物活性 靶点 体外研究 体内研究 4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉 试剂级价格
ChemicalBook  CAS数据库列表  4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉

4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉

4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉,153436-54-5,结构式
4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉
  • CAS号:153436-54-5
  • 英文名:PD 153035 HYDROCHLORIDE
  • 中文名:4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉
  • CBNumber:CB7249204
  • 分子式:C16H14BrN3O2
  • 分子量:360.21
  • MOL File:153436-54-5.mol
4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉化学性质
  • 熔点 :189-190 °C
  • 沸点 :472.1±45.0 °C(Predicted)
  • 密度 :1.499±0.06 g/cm3(Predicted)
  • 储存条件 :Keep in dark place,Inert atmosphere,2-8°C
  • 溶解度 :Soluble in DMSO (up to 5 mg/ml).
  • 酸度系数(pKa) :5.55±0.30(Predicted)
  • 形态 :White to off-white solid.
  • 颜色 :White or off-white
  • 稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉性质、用途与生产工艺

  • 生物活性 PD153035是一种特定的、有效的EGFR抑制剂,Ki值为5.2 pM。
  • 靶点
    TargetValue
    EGFR
    (Cell-free assay)
    5.2 pM(Ki)
  • 体外研究

    PD153035 (SU 5271) inhibits EGF-stimulated receptor autophosphorylation in A431 human epidermoid carcinoma cells, with an IC 50 of 14 nM. PD153035 (SU 5271) has little effect on PDGFR, FGFR, CSF-1 receptor, the insulin receptor, or on src tyrosine kinases at concentrations as high as 50 μM. PD153035 (SU 5271) rapidly suppresses autophosphorylation of the EGF receptor at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells and selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. PD153035 (SU 5271) causes a dose-dependent growth inhibition of EGF receptor-positive cell lines, beginning at less than micromolar concentrations, and the IC 50 is less than 1 pM in most cases.

  • 体内研究

    PD153035 (SU 5271) levels in the plasma and tumor rise to 50 and 22 μM within 15 minutes following a single i.p. dose of 80 mg/kg. While the plasma levels of PD153035 (SU 5271) falls below 1 μM by 3 hours, in the tumors it remains at micromolar concentrations for at least 12 hours. The tyrosine phosphorylation of the EGF receptor is rapidly suppressed by 80-90% in the tumors.

4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉上下游产品信息
上游原料
下游产品
4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉 试剂级价格
  • 更新日期:2024/01/25
  • 产品编号:HY-12013
  • 产品名称:4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉 PD153035 Hydrochloride
  • CAS编号:153436-54-5
  • 包装:5mg
  • 价格:500元
  • 更新日期:2024/01/25
  • 产品编号:HY-12013
  • 产品名称:4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉 PD153035 Hydrochloride
  • CAS编号:153436-54-5
  • 包装:10mM * 1mLin DMSO
  • 价格:550元
4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉生产厂家
  • 公司名称:济南精合医药科技有限公司
  • 联系电话:+86 (531) 88811783
  • 电子邮件:sales@trio-pharmatech.com (International market)
  • 国家:中国
  • 产品数:1856
  • 优势度:62
  • 公司名称:Wuhan NCE Biomedical Co.,Ltd.
  • 联系电话:4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
  • 电子邮件:
  • 国家:中国
  • 产品数:1494
  • 优势度:55
153436-54-5, 4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉相关搜索: