阿米卡星硫酸盐(5:9)

生物活性体外研究体内研究

阿米卡星硫酸盐(5:9)

CAS号:149022-22-0
英文名:Amikacin sulfate salt
中文名:阿米卡星硫酸盐(5:9)
CBNumber:CB6503073
分子式:C22H45N5O17S
分子量:683.68
MOL File:149022-22-0.mol

阿米卡星硫酸盐(5:9)化学性质

储存条件 :Inert atmosphere,2-8°C
溶解度 :H2O: soluble50mg/mL
形态 :solid
颜色 :white to off-white
InChIKey :HIBICIOPDUTNRR-BOEHXBESSA-N

安全信息

WGK Germany :2
RTECS号 :WK1961200

阿米卡星硫酸盐(5:9)性质、用途与生产工艺

生物活性 Amikacin sulfate (BAY 41-6551 sulfate) 是一种氨基糖苷类抗生素，也是一种卡那霉素的半合成类似物。Amikacin sulfate 具有杀菌作用，直接作用于 30S 和 50S 细菌核糖体亚基，可抑制蛋白质合成。Amikacin sulfate 对大多数革兰氏阴性细菌 (Gram-negative bacteria) (包括庆大霉素和妥布霉素抗性菌株) 非常有效。Amikacin sulfate 还抑制易感诺卡氏菌和非结核分枝杆菌引起的感染。
体外研究

Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides , Mycobacterium avium-intracellulare , and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi ).
Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD ₅₀ value of 453 μM.

体内研究

Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo.

Animal Model:	Male Fischer 344 rats (40-50-day-old)
Dosage:	320 mg/kg
Administration:	Subcutaneous injection; daily; for 10 days
Result:	Induced hearing loss in rats.