阿米卡星硫酸盐(5:9)
- CAS号:149022-22-0
- 英文名:Amikacin sulfate salt
- 中文名:阿米卡星硫酸盐(5:9)
- CBNumber:CB6503073
- 分子式:C22H45N5O17S
- 分子量:683.68
- MOL File:149022-22-0.mol
- 储存条件 :Inert atmosphere,2-8°C
- 溶解度 :H2O: soluble50mg/mL
- 形态 :solid
- 颜色 :white to off-white
- InChIKey :HIBICIOPDUTNRR-BOEHXBESSA-N
- WGK Germany :2
- RTECS号 :WK1961200
阿米卡星硫酸盐(5:9)性质、用途与生产工艺
- 生物活性 Amikacin sulfate (BAY 41-6551 sulfate) 是一种氨基糖苷类抗生素，也是一种卡那霉素的半合成类似物。Amikacin sulfate 具有杀菌作用，直接作用于 30S 和 50S 细菌核糖体亚基，可抑制蛋白质合成。Amikacin sulfate 对大多数革兰氏阴性细菌 (Gram-negative bacteria) (包括庆大霉素和妥布霉素抗性菌株) 非常有效。Amikacin sulfate 还抑制易感诺卡氏菌和非结核分枝杆菌引起的感染。
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体外研究
Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides , Mycobacterium avium-intracellulare , and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi ).
Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD 50 value of 453 μM. -
体内研究
Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo.
Animal Model: Male Fischer 344 rats (40-50-day-old) Dosage: 320 mg/kg Administration: Subcutaneous injection; daily; for 10 days Result: Induced hearing loss in rats. - 用途 抗感染药，用于治疗敏感菌所致尿路感染、败血症、皮肤感染、骨与关节感染、肺炎及下呼吸道感染等
- 公司名称：SIGMA
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- 国家：瑞士
- 产品数：6896
- 优势度：91
