生物活性 靶点 体外研究 体内研究 葫芦素 I 试剂级价格
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葫芦素 I

葫芦素 I,2222-07-3,结构式
葫芦素 I
  • CAS号:2222-07-3
  • 英文名:CUCURBITACIN I
  • 中文名:葫芦素 I
  • CBNumber:CB6480840
  • 分子式:C30H42O7
  • 分子量:514.65
  • MOL File:2222-07-3.mol
葫芦素 I化学性质
  • 熔点 :148-150°C
  • 沸点 :698.3±55.0 °C(Predicted)
  • 密度 :1.26±0.1 g/cm3(Predicted)
  • 储存条件 :-20°C
  • 溶解度 :≥22.45 mg/mL in DMSO; insoluble in EtOH; ≥51.2 mg/mL in H2O with ultrasonic
  • 酸度系数(pKa) :8.51±0.70(Predicted)
  • 形态 :solid
  • 颜色 :white to off-white
  • LogP :2.330 (est)
安全信息
  • 危险品标志 :Xi,T+
  • 危险类别码 :25-28
  • 安全说明 :1-22-45-36/37-28
  • 危险品运输编号 :UN 2811 6.1/PG 1
  • WGK Germany :3
  • RTECS号 :RC6200000
  • 毒性 :LD50 oral in mouse: 5mg/kg

葫芦素 I性质、用途与生产工艺

  • 生物活性 Cucurbitacin I 是 JAK2/STAT3 的天然选择性抑制剂,并具有有效的抗肿瘤活性。
  • 靶点

    JAK2

    STAT3

  • 体外研究

    Exposure of the COLO205 cells to Cucurbitacin I significantly decreases cell viability. The anticancer activity of Cucurbitacin I is accomplished by downregulating p-STAT3 and MMP-9 expression. PE-induced cell enlargement and upregulation of ANF and β-MHC are significantly suppressed by pretreatment of the cardiomyocytes with Cucurbitacin I. Notably, Cucurbitacin I also impaires connective tissue growth factor (CTGF) and MAPK signaling, pro-hypertrophic factors, as well as TGF-β/Smad signaling, the important contributing factors to fibrosis. Incubation of the Seax cell line with the Jak/Stat3 inhibitor Cucurbitacin I result in a time- and concentration-dependent decrease of P-Stat3 and Stat3. In freshly isolated Sz cells (n=3), Cucurbitacin I induces a concentration-dependent decrease in Stat3 expression whereas P-Stat3 is undetectable. Finally, incubation of freshly isolated Sz cells (n=4) with 30 μM Cucurbitacin I for 6 hours induces apoptosis in the large majority (73-91%) of tumor cells.

  • 体内研究

    No major side effects are noted throughout the study. It is shown that average tumor volumes at the end of the study are as follows: control, 616 mm 3 (±130); CQ, 580 mm 3 (±107); Cucurbitacin I, 346mm 3 (±79); and combination, 220mm 3 (±62). The differences in tumor volume between the Cucurbitacin I and control, combination and control, and combination and Cucurbitacin I arms are significant. Furthermore, combination-treated tumors exhibit a significantly lower average tumor weight at study termination than the control. Moreover, there was no effect on the body weights of mice.

葫芦素 I上下游产品信息
上游原料
下游产品
葫芦素 I 试剂级价格
  • 更新日期:2024/11/08
  • 产品编号:HY-N1405
  • 产品名称:葫芦素 I Cucurbitacin I
  • CAS编号:2222-07-3
  • 包装:1mg
  • 价格:1480元
  • 更新日期:2024/11/08
  • 产品编号:HY-N1405
  • 产品名称:葫芦素 I Cucurbitacin I
  • CAS编号:2222-07-3
  • 包装:5mg
  • 价格:3780元
葫芦素 I生产厂家
  • 公司名称:北京百灵威科技有限公司
  • 联系电话:010-82848833 400-666-7788
  • 电子邮件:jkinfo@jkchemical.com
  • 国家:中国
  • 产品数:94657
  • 优势度:76
  • 公司名称:TargetMol中国(陶术生物)
  • 联系电话:021-021-33632979 15002134094
  • 电子邮件:marketing@targetmol.com
  • 国家:中国
  • 产品数:7783
  • 优势度:58
  • 公司名称:上海喀露蓝科技有限公司
  • 联系电话:18149758185 18149758185
  • 电子邮件:sales-cpd@caerulumpharma.com
  • 国家:中国
  • 产品数:3466
  • 优势度:58
  • 公司名称:深圳振强生物技术有限公司
  • 联系电话:0755-0755-66853366 13670046396
  • 电子邮件:sales@chem-strong.com
  • 国家:中国
  • 产品数:18070
  • 优势度:56
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