溴化六甲铵

生物活性靶点体外研究体内研究溴化六甲铵试剂级价格

溴化六甲铵

CAS号:55-97-0
英文名:HEXAMETHONIUM BROMIDE
中文名:溴化六甲铵
CBNumber:CB6429850
分子式:C12H30Br2N2
分子量:362.19
MOL File:55-97-0.mol

溴化六甲铵化学性质

熔点 :~285 °C (dec.)
储存条件 :Inert atmosphere,Room Temperature
溶解度 :Water (Slightly)
形态 :Crystalline Powder and Agglomerates
颜色 :White
PH值 :pH (20g/l, 25℃) : 4.5～6.5
Merck :14,4688
BRN :3715749
InChIKey :FAPSXSAPXXJTOU-UHFFFAOYSA-L
CAS 数据库 :55-97-0(CAS DataBase Reference)
EPA化学物质信息 :1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, bromide (1:2) (55-97-0)

安全信息

安全说明 :22-24/25
WGK Germany :2
RTECS号 :BQ8575000
TSCA :Yes
海关编码 :29239000

溴化六甲铵性质、用途与生产工艺

生物活性 Hexamethonium Dibromide是一种神经中枢中选择性的神经元烟碱型AChR选择性拮抗剂。
靶点
Target Value
Dopamine subtype 2 receptor
AChR
体外研究
Hexamethonium Bromide能有效抵抗Ach和卡巴胆碱(CCh)对大鼠肩胛舌骨肌终板振幅的响应，EC50分别为300 μM和100 μM。0.6 μM 筒箭毒碱存在下，Hexamethonium Bromide (50-200 μM)使神经诱发的终板电流(e.p.cs)的振幅增加。在大鼠肌肉匀浆中，Hexamethonium Bromide也是乙酰胆碱酯酶活性的弱抑制剂，EC50为1.5 mM。在大鼠一侧膈肌中，Hexamethonium Bromide (200 μM)降低终板电流(e.p.cs) (降低~25%)和微终板电流(m.e.p.cs) (降低~20%)衰变的时间常数。在低频刺激(0.5-2 Hz)下，Hexamethonium Bromide (200 μM)增加30-40% e.p.c.量子含量。

体内研究

Hexamethonium Bromide (0.2-25 mg/kg; i.v.) significantly reduces the renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP) and heart rate (HR) in the Wistar rats and the spontaneously hypertensive rats (SHRs).
Hexamethonium Bromide (0.2-1.0 mg/kg; i.v.) treatments show no significant differences in the RSNA, MAP or HR between Wistar rats and SHRs.
Hexamethonium Bromide (5.0-25 mg/kg; i.v.) results in a greater reduction in the RSNA and MAP in SHRs compared with Wistar rats.

Animal Model:	Male normotensive Wistar rats (280-320 g), SHRs
Dosage:	0.2 mg/kg, 1.0 mg/kg, 5.0 mg/kg, 25 mg/kg
Administration:	Intravenous injection
Result:	Significantly reduced the RSNA, MAP and HR in the Wistar rats and the SHRs.