溴夫定
- CAS号:69304-47-8
- 英文名:Brivudine
- 中文名:溴夫定
- CBNumber:CB6143433
- 分子式:C11H13BrN2O5
- 分子量:333.14
- MOL File:69304-47-8.mol
- 熔点 :165°C
- 密度 :1.7800 (rough estimate)
- 折射率 :1.6520 (estimate)
- 储存条件 :Inert atmosphere,2-8°C
- 溶解度 :DMSO (Slightly), Methanol (Slightly)
- 形态 :Solid
- 酸度系数(pKa) :8.37±0.10(Predicted)
- 颜色 :Off-White
- 水溶解性 :Soluble in water and methanol.
- Merck :14,1378
- InChIKey :ODZBBRURCPAEIQ-CXYVBZRVSA-N
- 安全说明 :24/25
- WGK Germany :3
- RTECS号 :YU7355000
- 海关编码 :29349990
溴夫定性质、用途与生产工艺
- 生物活性 Brivudine是具有抗病毒活性的胸苷类似物,用于早期急性带状疱疹的研究。
-
体外研究
Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage.
-
体内研究
At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia.
- 类别 有毒物品
- 可燃性危险特性 热分解排出有毒溴化物和氮氧化物烟雾
- 储运特性 库房通风低温干燥
- 灭火剂 水,干粉、干砂、二氧化碳、泡沫、1211灭火剂
- 更新日期：2024/11/11
- 产品编号：XW6930447803
- 产品名称：溴夫定
- CAS编号：69304-47-8
- 包装：1G
- 价格：863元
- 更新日期：2024/11/11
- 产品编号：XW6930447801
- 产品名称：溴夫定
- CAS编号：69304-47-8
- 包装：50MG
- 价格：93元
- 公司名称：R&D Scientific Inc.
- 联系电话：+1-2266000236
- 电子邮件：sales@rdscientific.com
- 国家：加拿大
- 产品数：1627
- 优势度：58
- 公司名称：Syntech Pharmachem Ltd.
- 联系电话：--
- 电子邮件：kevinl@syntechpharmachem.com
- 国家：加拿大
- 产品数：386
- 优势度：58
