生物活性 靶点 体外研究 体内研究 L-犬尿氨酸 试剂级价格
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L-犬尿氨酸

L-犬尿氨酸,2922-83-0,结构式
L-犬尿氨酸
  • CAS号:2922-83-0
  • 英文名:L-KYNURENINE
  • 中文名:L-犬尿氨酸
  • CBNumber:CB6142966
  • 分子式:C10H12N2O3
  • 分子量:208.21
  • MOL File:2922-83-0.mol
L-犬尿氨酸化学性质
  • 熔点 :219 °C
  • 沸点 :466.6±45.0 °C(Predicted)
  • 密度 :1.343±0.06 g/cm3(Predicted)
  • 折射率 :-33 ° (C=0.4, H2O)
  • 储存条件 :under inert gas (nitrogen or Argon) at 2–8 °C
  • 溶解度 :Soluble in DMSO (up to 2 mg/ml) or in Water (up to 2 mg/ml).
  • 形态 :crystalline
  • 酸度系数(pKa) :2.21±0.23(Predicted)
  • 颜色 :light yellow
  • 旋光性 (optical activity) :-30.525 (H2O)
  • Merck :14,5328
  • 稳定性 :Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
  • InChIKey :YGPSJZOEDVAXAB-QMMMGPOBSA-N
  • CAS 数据库 :2922-83-0(CAS DataBase Reference)
安全信息
  • WGK Germany :3
  • RTECS号 :CY9049700
  • 海关编码 :2922500090

L-犬尿氨酸性质、用途与生产工艺

  • 生物活性 L-Kynurenine ((S)-Kynurenine)是一种 aryl hydrocarbon receptor (AhR) 激动剂。 L-Kynurenine是氨基酸L-色氨酸的代谢产物和色氨酸代谢途径的中心化合物,可用于生产烟酸(niacin)。
  • 靶点

    Human Endogenous Metabolite

  • 体外研究

    Kynurenine and its further breakdown products carry out diverse biological functions, including dilating blood vessels during inflammation and regulating the immune response. Some cancers increase kynurenine production, which increases tumor growth. L-kynurenine (Kyn) is an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype. Kynurenine activates AHR signaling at physiological concentrations in H1L7.5c3 cells and acts as an AHR agonist after a 24-hr exposure by inducing the AHR-regulated luciferase gene in H1L7.5c3 mouse hepatocyte cells.

  • 体内研究

    Kynurenine dilates arteries from rats as well as humans via Kv7 channels in the vascular smooth muscle. In rats, this tryptophan metabolite causes hypotension, which is partly counteracted by Kv7 channel inhibition. L-kynurenine administered 1 h before the hypoxia-ischemia shows a dose-dependent significant neuroprotective effect, with complete protection at a dose of 300 mg/kg. The induction of c-fos immunoreactivity in cerebral cortex is also blocked by this dose of L-kynurenine.

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L-犬尿氨酸 试剂级价格
  • 更新日期:2024/11/11
  • 产品编号:XW292283001
  • 产品名称:L-犬尿氨酸水合物
  • CAS编号:2922-83-0
  • 包装:25MG
  • 价格:179元
  • 更新日期:2024/11/08
  • 产品编号:HY-104026
  • 产品名称:L-犬尿氨酸 L-Kynurenine
  • CAS编号:2922-83-0
  • 包装:50mg
  • 价格:500元
L-犬尿氨酸生产厂家
  • 公司名称:TOKYO CHEMICAL INDUSTRY CO., LTD.
  • 联系电话:03-36680489
  • 电子邮件:Sales-JP@TCIchemicals.com
  • 国家:日本
  • 产品数:28387
  • 优势度:80
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