2922-83-0
基本信息
L-犬尿氨酸
L-犬尿酸
L-2-AMINO-4-[2-AMINOPHENYL]-4-OXOBUTANOIC ACID
L-KYNURENINE
L-kynurenine free base
β-Anthraniloyl-L-alanine
β-Anthraniloyl-L-alanine, L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
L-Kynurenine Hydrate
(S)-2-Amino-4-oxo-4-(2-aminophenyl)butanoic acid
(S)-α,2-Diamino-γ-oxobenzenebutanoic acid
3-(2-Aminobenzoyl)alanine
3-(2-Aminobenzoyl)-L-alanine
物理化学性质
| 熔点 | 219 °C |
| 沸点 | 466.6±45.0 °C(Predicted) |
| 密度 | 1.343±0.06 g/cm3(Predicted) |
| 折射率 | -33 ° (C=0.4, H2O) |
| 储存条件 | Keep in dark place,Inert atmosphere,2-8°C |
| 储存条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
| 溶解度 | 可溶于DMSO（高达2mg/ml）或水（高达2mg/ml）。 |
| 酸度系数(pKa) | 2.21±0.23(Predicted) |
| 形态 | crystalline |
| 颜色 | light yellow |
| Merck | 14,5328 |
| Merck | 5328 |
| 稳定性 | 可在-20°下的DMSO或蒸馏水中的溶液中储存长达3个月。 |
| InChIKey | YGPSJZOEDVAXAB-QMMMGPOBSA-N |
| CAS 数据库 | 2922-83-0(CAS DataBase Reference) |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302-H315-H319-H335 |
| 防范说明 | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | 3 |
| WGK Germany | 3 |
| RTECS号 | CY9049700 |
| 海关编码 | 2922500090 |
图谱信息
L-犬尿氨酸(2922-83-0)质谱(MS)L-犬尿氨酸(2922-83-0)核磁图(13CNMR)L-犬尿氨酸(2922-83-0)红外图谱(IR1)L-犬尿氨酸(2922-83-0)红外图谱(IR2)知名试剂公司产品信息
L-Kynurenine Hydrate,>98.0%(T)(2922-83-0) TCI Shanghai
L-犬尿氨酸价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-104026 | L-犬尿氨酸 L-Kynurenine | 2922-83-0 | 50mg | 500元 |
| 2024/01/25 | HY-104026 | L-犬尿氨酸 L-Kynurenine | 2922-83-0 | 10mM * 1mLin DMSO | 550元 |
| 2024/01/16 | S5839 | L-犬尿氨酸 L-Kynurenine | 2922-83-0 | 5mg | 794.52元 |
常见问题列表
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Human Endogenous Metabolite
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Kynurenine and its further breakdown products carry out diverse biological functions, including dilating blood vessels during inflammation and regulating the immune response. Some cancers increase kynurenine production, which increases tumor growth. L-kynurenine (Kyn) is an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype. Kynurenine activates AHR signaling at physiological concentrations in H1L7.5c3 cells and acts as an AHR agonist after a 24-hr exposure by inducing the AHR-regulated luciferase gene in H1L7.5c3 mouse hepatocyte cells.
Kynurenine dilates arteries from rats as well as humans via Kv7 channels in the vascular smooth muscle. In rats, this tryptophan metabolite causes hypotension, which is partly counteracted by Kv7 channel inhibition. L-kynurenine administered 1 h before the hypoxia-ischemia shows a dose-dependent significant neuroprotective effect, with complete protection at a dose of 300 mg/kg. The induction of c-fos immunoreactivity in cerebral cortex is also blocked by this dose of L-kynurenine.