奈康唑
- CAS号:130726-68-0
- 英文名:Neticonazole
- 中文名:奈康唑
- CBNumber:CB61075063
- 分子式:C17H22N2OS
- 分子量:302.43
- MOL File:130726-68-0.mol
- 熔点 :37-39°
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: 250 mg/mL (826.64 mM)
- 形态 :Solid
- 颜色 :White to off-white
奈康唑性质、用途与生产工艺
- 生物活性 Neticonazole 是一种咪唑衍生物，也是一种有效且长效的抗真菌剂。Neticonazole 具有抗感染和抗癌作用。
-
靶点
Fungal
-
体外研究
Neticonazole (10 µM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels.
Neticonazole (0-10 µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells.
Neticonazole is also an orally active exosome biogenesis and secretion inhibitor.Western Blot Analysis
Cell Line: C4-2B cells Concentration: 10 µM Incubation Time: 48 hours Result: Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels. -
体内研究
Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells.
Animal Model: Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells Dosage: 1 ng/kg, 10 ng/kg and 100 ng/kg Administration: Oral gavage; daily; for 15 days Result: Significantly improved the survival of IDB mice with CRC xenograft tumors.
- 更新日期：2024/11/08
- 产品编号：HY-106541
- 产品名称：奈康唑 Neticonazole
- CAS编号：130726-68-0
- 包装：25mg
- 价格：750元
- 更新日期：2024/11/08
- 产品编号：HY-106541
- 产品名称：奈康唑 Neticonazole
- CAS编号：130726-68-0
- 包装：10mM * 1mLin DMSO
- 价格：830元
- 公司名称：CHEMICAL LAND21
- 联系电话：--
- 电子邮件：sales21@chemicalland21.com
- 国家：韩国
- 产品数：6303
- 优势度：74
