奈康唑
奈康唑 用途与合成方法
Fungal
Neticonazole (10 µM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels.
Neticonazole (0-10 µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells.
Neticonazole is also an orally active
exosome biogenesis and secretion
inhibitor.
Western Blot Analysis
| Cell Line: | C4-2B cells |
| Concentration: | 10 µM |
| Incubation Time: | 48 hours |
| Result: | Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels. |
Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells.
| Animal Model: | Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells |
| Dosage: | 1 ng/kg, 10 ng/kg and 100 ng/kg |
| Administration: | Oral gavage; daily; for 15 days |
| Result: | Significantly improved the survival of IDB mice with CRC xenograft tumors. |
奈康唑 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-106541 | 奈康唑 | 130726-68-0 | 25mg | 750 |
| 2024-04-30 | HY-106541 | 奈康唑 | 130726-68-0 | 10mM * 1mLin DMSO | 830 |
