ChemicalBook CAS数据库列表 RILMENIDINE HEMIFUMARATE SALT
RILMENIDINE HEMIFUMARATE SALT
- CAS号:207572-68-7
- 英文名:RILMENIDINE HEMIFUMARATE SALT
- 中文名:RILMENIDINE HEMIFUMARATE SALT
- CBNumber:CB5972920
- 分子式:2C10H16N2O.C4H4O4
- 分子量:476.57
- MOL File:207572-68-7.mol
RILMENIDINE HEMIFUMARATE SALT化学性质
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: >10mg/mL
- 形态 :solid
- 颜色 :white
安全信息
- 安全说明 :22-24/25
- WGK Germany :3
- RTECS号 :RP7207400
RILMENIDINE HEMIFUMARATE SALT性质、用途与生产工艺
- 生物活性 Rilmenidine hemifumarate 是一种新型的抗高血压药物和口服活性选择性 I1 咪唑啉受体 (I1 imidazoline receptor) 激动剂。Rilmenidine hemifumarate 也是一种 α2 肾上腺素受体激动剂。Rilmenidine phosphate 诱导自噬 (autophagy)。Rilmenidine hemifumarate 可通过减少交感神经过度活跃而发挥中枢作用，并通过抑制 Na+/H+ 反向转运而在肾脏中发挥作用。Rilmenidine hemifumarate可调节白血病细胞增殖，刺激促凋亡蛋白 Bax，从而诱导人白血病 K562 细胞线粒体通路的紊乱和凋亡。
-
体外研究
Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors.
Rilmenidine (25-100 μM; 24 hours) inhibits K562 cell proliferation.Cell Viability Assay
Cell Line: K562 cells Concentration: 25, 50, 100 μM Incubation Time: 24 hours Result: Dose-dependently inhibited K562 colony formation. -
体内研究
Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age.
Rilmenidine decreases levels of mutant huntingtin.
RILMENIDINE HEMIFUMARATE SALT上下游产品信息
上游原料
下游产品
RILMENIDINE HEMIFUMARATE SALT生产厂家
- 公司名称：CLEARSYNTH LABS LTD.
- 联系电话：--
- 电子邮件：sales@clearsynth.com
- 国家：印度
- 产品数：6257
- 优势度：58
207572-68-7, RILMENIDINE HEMIFUMARATE SALT相关搜索:
