磺胺氯吡嗪钠
- CAS号:102-65-8
- 英文名:N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO
- 中文名:磺胺氯吡嗪钠
- CBNumber:CB5854974
- 分子式:C10H9ClN4O2S
- 分子量:284.72
- MOL File:102-65-8.mol
- 熔点 :234.8-235.4 °C
- 沸点 :495.7±55.0 °C(Predicted)
- 密度 :1.588±0.06 g/cm3(Predicted)
- 储存条件 :2-8°C(protect from light)
- 溶解度 :DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
- 形态 :Solid
- 酸度系数(pKa) :4.83±0.10(Predicted)
- 颜色 :White to Off-White
磺胺氯吡嗪钠性质、用途与生产工艺
- 生物活性 Sulfalozine sodium (Sulfaclozine sodium, Sulfachlopryrazine sodium) 是一种抗原生动物药，用于球虫病的研究。
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靶点
Bacterial; Parasite
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体外研究
The elimination of Sulfaclozine in the three systems: UV/TiO 2 , UV/K 2 S 2 O 8 , and UV/TiO 2 /K 2 S 2 O 8 . Sulfaclozine is weakly adsorbed on the surface of TiO 2 at pH 7 (< 5%) but efficiently eliminated with the following three systems: UV/TiO 2 , UV/K 2 S 2 O 8 , and UV/TiO 2 /K 2 S 2 O 8 in ultra pure water. Moreover, 12 of Sulfaclozine by-products are identified and reaction pathways show that, in addition of • OH and SO 4 •− radicals, the conduction-band electrons are responsible for the formation of some main by-products either directly or by the formation of superoxide radicals.
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体内研究
Sulfaclozine (60 mg/kg; intravenous injection or oral administration; male broiler chickens) can be used primarily for the treatment of parasitic and microbial infections of the digestive tract rather than for the treatment of systemic infections.
Animal Model: 14 male broiler chickens (30-day-old) Dosage: 60 mg/kg Administration: Intravenous injection or oral administration (Pharmacokinetic Analysis) Result: Serum drug concentrations at 0.083, 0.50, 2, 6, 24 and 72h were determined to be 99.62, 83.50, 72.68, 58.43, 38.66 and 13.14 μg/mL, respectively, by intravenous injection. By oral administration were determined as 4.33, 7.95, 16.46, 22.88, 16.03 and 5.74 μg/mL, respectively. - 用途 磺胺氯吡嗪钠为抗球虫的专用磺胺药，广泛用于畜禽球虫病。本品可争夺二氢叶酸合成酶影响二氢叶酸的合成，从而抑制细菌和球虫的生长繁殖。本品对家禽球虫的作用特点与磺胺喹沙啉相似，但具更强的抗菌作用，甚至可治疗禽霍乱及鸡伤寒因此最适合球虫病爆发时治疗用。
- 用途 本品为抗球虫的专用磺胺药，广泛用于畜禽球虫病。本品可争夺二氢叶酸合成酶影响二氢叶酸的合成，从而抑制细菌和球虫的生长繁殖。本品对家禽球虫的作用特点与磺胺喹沙啉相似，但具更强的抗菌作用，甚至可治疗禽霍乱及鸡伤寒因此最适合球虫病爆发时治疗用。
- 用途 磺胺类抗菌药，用于禽畜大肠杆菌和巴式杆菌感染，与甲氧苄啶与蔗糖配置而成复方磺胺氯哒嗪钠盐效果更加，对磺胺类药过敏者忌用，肾功能减退者慎用。
- 更新日期：2024/11/08
- 产品编号：HY-19285
- 产品名称：Sulfaclozine
- CAS编号：
- 包装：5 mg
- 价格：300元
- 更新日期：2024/11/08
- 产品编号：HY-19285
- 产品名称：Sulfaclozine
- CAS编号：
- 包装：10 mg
- 价格：450元
- 公司名称：CHEMICAL LAND21
- 联系电话：--
- 电子邮件：sales21@chemicalland21.com
- 国家：韩国
- 产品数：6303
- 优势度：74
