沙加霉素

生物活性靶点体外研究体内研究沙加霉素试剂级价格

沙加霉素

CAS号:66803-19-8
英文名:MICRONOMICIN SULFATE
中文名:沙加霉素
CBNumber:CB5390867
分子式:C20H43N5O11S
分子量:561.65
MOL File:66803-19-8.mol

沙加霉素化学性质

熔点 :>205°C (dec.)
沸点 :667℃
RTECS号 :WK2196000
闪点 :>110°(230°F)
储存条件 :Hygroscopic, Refrigerator, under inert atmosphere
溶解度 :DMSO (Very Slightly, Heated, Sonicated), Water (Slightly)
形态 :Solid
颜色 :White to Pale Yellow
水溶解性 :Freely soluble in water
稳定性 :Hygroscopic

沙加霉素化学药品说明书

硫酸小诺霉素|药典2005版
硫酸小诺霉素片

沙加霉素性质、用途与生产工艺

生物活性 Micronomicin sulfate (Gentamicin C2b sulfate) 是从 Micromonospora 中分离出来的氨基糖苷抗生素 (antibiotic)。Micronomicin sulfate 是一种接近庆大霉素类抗生素的广谱抗生素，对假单胞菌、变形杆菌、肺炎克雷伯菌、沙雷菌等具有高的抑制活性 (MIC=0.001-8.3 μg/ml)。
靶点

MIC: 0.001-8.3 μg/ml ( Pseudomonas , Proteus , Klebsiella pneumoniae , Serratia )
体外研究

Micronomicin has a potent antibacterial activity, it is active against Staphylococcus aureus FDA 209 P, Staphylococcus aureus with the minimal inhibitory values of 0.01 μg/ml. It is also against Escherichia coli St.M. 589, Baker 2, F 14-BK, and R5/W677 with the minimal inhibitory values of 0.75 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml. And it is active against Pseudomonas aeruginosa strains and lebsiella pneumoniae strains (MICs = 0.03-17.5 μg/ml).

体内研究

Micronomicin sulfate is highly active against various bacterial infections in mice, and has an intravenous acute LD ₅₀ in mice of 93 mg/kg.Micronomicin sulfate (intravenous injection; 4-100 mg/kg; 30 days) is injected for subacute toxicity study. The wistar rats dies at the dose level of 100 mg/kg (10 out of 30 animals): renal disorders and ataxia. The renal histological disorders occurrs mainly at the dose levels of 25 mg/kg and over.