沙加霉素
- CAS号:66803-19-8
- 英文名:MICRONOMICIN SULFATE
- 中文名:沙加霉素
- CBNumber:CB5390867
- 分子式:C20H43N5O11S
- 分子量:561.65
- MOL File:66803-19-8.mol
- 熔点 :>205°C (dec.)
- 沸点 :667℃
- RTECS号 :WK2196000
- 闪点 :>110°(230°F)
- 储存条件 :Hygroscopic, Refrigerator, under inert atmosphere
- 溶解度 :DMSO (Very Slightly, Heated, Sonicated), Water (Slightly)
- 形态 :Solid
- 颜色 :White to Pale Yellow
- 水溶解性 :Freely soluble in water
- 稳定性 :Hygroscopic
沙加霉素 化学药品说明书
硫酸小诺霉素|药典2005版
硫酸小诺霉素片
沙加霉素性质、用途与生产工艺
- 生物活性 Micronomicin sulfate (Gentamicin C2b sulfate) 是从 Micromonospora 中分离出来的氨基糖苷抗生素 (antibiotic)。Micronomicin sulfate 是一种接近庆大霉素类抗生素的广谱抗生素，对假单胞菌、变形杆菌、肺炎克雷伯菌、沙雷菌等具有高的抑制活性 (MIC=0.001-8.3 μg/ml)。
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靶点
MIC: 0.001-8.3 μg/ml ( Pseudomonas , Proteus , Klebsiella pneumoniae , Serratia )
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体外研究
Micronomicin has a potent antibacterial activity, it is active against Staphylococcus aureus FDA 209 P, Staphylococcus aureus with the minimal inhibitory values of 0.01 μg/ml. It is also against Escherichia coli St.M. 589, Baker 2, F 14-BK, and R5/W677 with the minimal inhibitory values of 0.75 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml. And it is active against Pseudomonas aeruginosa strains and lebsiella pneumoniae strains (MICs = 0.03-17.5 μg/ml).
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体内研究
Micronomicin sulfate is highly active against various bacterial infections in mice, and has an intravenous acute LD 50 in mice of 93 mg/kg.Micronomicin sulfate (intravenous injection; 4-100 mg/kg; 30 days) is injected for subacute toxicity study. The wistar rats dies at the dose level of 100 mg/kg (10 out of 30 animals): renal disorders and ataxia. The renal histological disorders occurrs mainly at the dose levels of 25 mg/kg and over.
Animal Model: Wistar rats Dosage: 4, 10, 25, 63 mg/kg and 100 mg/kg Administration: Intravenous injection; 30 days Result: Led to death of rat at 100 mg/kg. - 用途 属抗生素类药
- 用途 用于革兰阴性杆菌所致的各种感染，如菌血症、呼吸系统、胆管、尿路感染等。局部滴眼治疗敏感菌引起的眼睑炎、泪囊炎、结膜炎、角膜炎等。
- 更新日期：2024/11/08
- 产品编号：HY-108307
- 产品名称：沙加霉素 Micronomicin sulfate
- CAS编号：
- 包装：25 mg
- 价格：344元
- 更新日期：2024/11/08
- 产品编号：HY-108307
- 产品名称：沙加霉素 Micronomicin sulfate
- CAS编号：66803-19-8
- 包装：50mg
- 价格：630元
- 公司名称：CLEARSYNTH LABS LTD.
- 联系电话：--
- 电子邮件：sales@clearsynth.com
- 国家：印度
- 产品数：6257
- 优势度：58
