ChemicalBook CAS数据库列表 CCG1423
CCG1423
- CAS号:285986-88-1
- 英文名:CCG-1423
- 中文名:CCG1423
- CBNumber:CB52446676
- 分子式:C18H13ClF6N2O3
- 分子量:454.75
- MOL File:285986-88-1.mol
CCG1423化学性质
- 储存条件 :Sealed in dry,Store in freezer, under -20°C
- 溶解度 :DMSO: soluble5mg/mL, clear (warmed)
- 形态 :White solid
- 颜色 :white to beige
安全信息
- WGK Germany :3
- 海关编码 :2924.29.7790
CCG1423性质、用途与生产工艺
- 生物活性 CCG-1423是一种特定的 RhoA 通路抑制剂，能够抑制SRF介导的转录。
- 体外研究 CCG-1423 selectively inhibits SRF-mediated transcription activated by Rho pathway signaling, and specifically inhibits LPA-stimulated DNA synthesis. CCG-1423 also selectively inhibits the proliferation of RhoC-overexpressing melanoma cells (A375M2 and SK-Mel-147), and strongly suppresses the Rho-dependent invasion by PC-3 cells. CCG-1423 in combination with LY294002 enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. In H9c2 cells, CCG-1423 inhibits MRTF nuclear localization, and completely blocks STARS proximal reporter activity. CCG-1423, as a Rho/MRTF/SRF pathway inhibitor, also represses both matrix-stiffness and TGF-beta-induced fibrogenesis in human colonic myofibroblasts.
CCG1423上下游产品信息
上游原料
下游产品
CCG1423 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-13991
- 产品名称：CCG-1423
- CAS编号：
- 包装：5 mg
- 价格：406元
- 更新日期：2024/11/08
- 产品编号：HY-13991
- 产品名称：CCG1423 CCG-1423
- CAS编号：285986-88-1
- 包装：10mg
- 价格：650元
CCG1423生产厂家
- 公司名称：TOKYO CHEMICAL INDUSTRY CO., LTD.
- 联系电话：03-36680489
- 电子邮件：Sales-JP@TCIchemicals.com
- 国家：日本
- 产品数：28387
- 优势度：80
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