VAS2870

CAS号:722456-31-7
英文名:1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide
中文名:VAS2870
CBNumber:CB51977298
分子式:C18H12N6OS
分子量:360.39
MOL File:722456-31-7.mol

VAS2870化学性质

沸点 :627.0±65.0 °C(Predicted)
密度 :1.53±0.1 g/cm3(Predicted)
储存条件 :room temp
溶解度 :DMSO: ≥5mg/mL
形态 :Tan solid
酸度系数(pKa) :0.85±0.30(Predicted)
颜色 :white to beige
稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

安全信息

VAS2870性质、用途与生产工艺

简介 VAS-2870 (722456-31-7) 是一种 NAD(P)H 氧化酶 (Nox) 抑制剂。其可抑制 HL-60 细胞中由PMA 诱导的氧化反应(IC50=2 μM)，可增强 TGF-β 诱导的肝肿瘤细胞的凋亡。
生物活性 VAS2870是一种泛NADPH oxidase(NOX)抑制剂。
靶点
Target Value
NADPH oxidase
()
体外研究

VAS2870 is effective to suppress PDGF-BB-dependent activation of NADPH oxidase and subsequent production of intracellular ROS. Furthermore, VAS2870 suppresses PDGF-BB-dependent chemotaxis, but not DNA synthesis. Preincubation with VAS2870 (10 and 20 μM) completely abolishes PDGF-mediated NADPH oxidase activation and ROS production. Preincubation with VAS2870 (0.1-20 μM) does not affect PDGF-induced cell cycle progression. However, it abolishes PDGF-dependent chemotaxis of VSMC in a concentration-dependent manner (100% inhibition at 10 μM). VAS2870 inhibits dose-dependently autocrine increase of cell number in FaO rat hepatoma cells, and almost completely blocked ROS production and thymidine incorporation when used at 25 mM. VAS2870 blocks serum-dependent cell growth of FaO rat hepatoma cells. VAS2870 inhibits proliferation of different human hepatocellular carcinoma (HCC) cell lines. VAS2870 pretreatment enhances TGF-b-mediated apoptosis of FaO rat hepatoma cells.

VAS2870上下游产品信息

上游原料

下游产品

VAS2870 试剂级价格

VAS2870生产厂家

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Target	Value
NADPH oxidase ()