甘珀酸钠
- CAS号:7421-40-1
- 英文名:Carbenoxolone disodium
- 中文名:甘珀酸钠
- CBNumber:CB3680281
- 分子式:C34H48Na2O7
- 分子量:614.72
- MOL File:7421-40-1.mol
- 熔点 :>275°C (dec.)
- 储存条件 :2-8°C
- 溶解度 :Methanol (Slightly), Water (Slightly)
- 形态 :Solid
- 酸度系数(pKa) :pKa1 4.18; pKa2 5.52(at 25℃)
- 颜色 :White to Off-White
- 水溶解性 :Soluble in water to 100 mM.
- 稳定性 :Hygroscopic
- LogP :7.083 (est)
- CAS 数据库 :7421-40-1(CAS DataBase Reference)
甘珀酸钠 化学药品说明书
甘珀酸钠胶囊
甘珀酸钠片
甘珀酸钠性质、用途与生产工艺
- 生物活性 Carbenoxolone disodium 是甘草酸 (HY-N0184) 的活性代谢物和人 11β-HSD 和细菌 3α, 20β-HSD 的抑制剂。Carbenoxolone disodium 是一种缝隙连接的解耦剂 (gap junctions) 和并且可以有效抑制牛痘病毒生长。Carbenoxolone disodium 可用于研究消化性、食道和口腔溃疡和炎症的相关研究。
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靶点
IC50: human 11β-HSD; bacterial 3α, 20β-HSD; gap junction; Vaccinia virus
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体外研究
Carbenoxolone disodium (6-150 μM; pre-treatment 1 hour) inhibits Vaccinia virus (VACV) replication in a gap junction-independent in HaCaT cells, and it has toxicity effects on VACV-A5L-EGFP infected cells at 48 h.Carbenoxolone (30 μM; pre-treatment 1 hour) does not upregulate PP2A expression, but induces the late protein A27 expression in hacat cells.
Cell Viability Assay
Cell Line: HaCaT cells Concentration: 6 μM, 12 μM, 30 μM, 60 μM, 150 μM Incubation Time: Pre-treatment 1 hour Result: Had no toxicity until 48 hours at high dose in virus-infected cells. Western Blot Analysis
Cell Line: HaCaT cells Concentration: 30 μM Incubation Time: Pre-treatment 1 hour Result: Presented an obvious upregulation of A27. -
体内研究
Carbenoxolone (intraperitoneal injection; 100, 200 and 300 mg/kg; 30, 60 and 60 min before Diazepam) does not induce a muscle relaxant activity and shows muscle relaxant activity compared to normal saline, and this effect was more than diazepam in the traction test.Carbenoxolone (intraperitoneal injection; 100, 200 and 300 mg/kg; 30, 60 and 60 min before Pentylenetetrazole) significantly increases sleeping time and decreases latency in mice as a dose-dependent manner in Pentylenetetrazole (PTZ) Seizure model. The ED 50 value is 83.3 mg/kg (%95 CL:556.29).
Animal Model: Male BALB/c mice Dosage: 100, 200 and 300 mg/kg Administration: Intraperitoneal injection; 30, 60 and 60 min before Pentylenetetrazole Result: Significantly increased the sleeping time in mice. - 类别 有毒物质
- 毒性分级 中毒
- 急性毒性 口服-大鼠 LD50: 2450 毫克/公斤; 腹腔-小鼠 LD50: 120 毫克/公斤
- 可燃性危险特性 热分解排出有毒氧化钠烟雾
- 储运特性 库房低温通风干燥
- 灭火剂 水, 二氧化碳, 泡沫, 干粉
- 更新日期：2024/11/08
- 产品编号：HY-B1367
- 产品名称：Carbenoxolone disodium
- CAS编号：
- 包装：5 mg
- 价格：225元
- 更新日期：2024/11/08
- 产品编号：HY-B1367
- 产品名称：Carbenoxolone disodium
- CAS编号：
- 包装：10 mg
- 价格：360元
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
