生物活性 体外研究 体内研究 氯塞酮 试剂级价格
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氯塞酮

氯塞酮,77-36-1,结构式
氯塞酮
  • CAS号:77-36-1
  • 英文名:Chlortalidone
  • 中文名:氯塞酮
  • CBNumber:CB3233539
  • 分子式:C14H11ClN2O4S
  • 分子量:338.77
  • MOL File:77-36-1.mol
氯塞酮化学性质
安全信息

氯塞酮 MSDS


Chlorthalidone

氯塞酮 化学药品说明书


氯噻酮|药典2005版
氯噻酮—氯噻酮的测定—高效液相色谱法|药物分析方法信息

氯塞酮性质、用途与生产工艺

  • 生物活性 Chlortalidone (Chlortalidone)是一种利尿剂,用于治疗高血压。
  • 体外研究

    Chlorthalidone通过抑制钠离子通过肾小管上皮细胞的转运,增加钠,氯,和水排泄到肾内腔。它作用的主要位点是髓袢上升支的皮质稀释段。通过增加钠到远端肾小管的转运,chlorthalidone通过钠钾交换机制间接增加钾分泌(即顶端ROMK/Na 通道耦合基底侧NKATPases)。

  • 体内研究

    Chlorthalidone is a thiazide-like diuretic. After oral intake, peak serum concentrations are achieved in 2-6 hours. The half-life of Chlorthalidone is approximately 42 (range 29-55) hours, reaching 45-60 hours after long-term dosing. However, interindividual variability in the half-life of Chlorthalidone is wide. Chlorthalidone is excreted unchanged by the kidneys. The natriuretic effect of Chlorthalidone is maximal at 18 hours and lasts more than 48 hours. Comparing different doses of Chlorthalidone, it has been observed that 25 mg daily is nearly as effective as higher doses, but with less risk of hypokalemia. Chlorthalidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not. The effectiveness of Chlorthalidone or magnesium hydroxide is examined in the prevention of recurrent calcium oxalate kidney calculi. In a double-blind random allocation design daily dosages of 25 or 50 mg. Chlorthalidone, 650 or 1,300 mg. magnesium hydroxide, or an identical placebo are administered. All groups showed significantly decreased calculous events compared to the pretreatment rates. During the trial 56.1 per cent fewer calculi than predicted developed in the placebo group (p less than 0.01), whereas the groups receiving low and high dosage magnesium hydroxide showed 73.9 and 62.3 per cent fewer calculi, respectively (p less than 0.001 and less than 0.01, respectively). Chlorthalidone treatment results in a 90.1 per cent decrease from predicted rates and both dosages yielded similar results. When the treatments are compared Chlorthalidone is significantly better than the placebo or magnesium hydroxide (p less than 0.01). The large decreases in calculous events seen when placebo or ineffective therapy is given underscore the positive treatment bias that occurs when historical controls are used and they demonstrate the need for proper experimental design.

  • 化学性质  白色结晶性粉末。熔点224-226℃(分解)。微溶于水、乙醇、氯仿,溶于热乙醇。无臭,无味。
  • 用途  利尿药,用于心脏性,肾性及其他水肿病。
  • 生产方法  由2-(3-氨基-4-氯苯甲酰)苯甲酸[118-04-7]经重氮化、置换、氯磺化、环合、胺化而得。
氯塞酮上下游产品信息
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下游产品
氯塞酮 试剂级价格
  • 更新日期:2024/01/25
  • 产品编号:HY-15833
  • 产品名称:氯塞酮 Chlorthalidone
  • CAS编号:77-36-1
  • 包装:50mg
  • 价格:200元
  • 更新日期:2024/01/25
  • 产品编号:HY-15833
  • 产品名称:氯塞酮 Chlorthalidone
  • CAS编号:77-36-1
  • 包装:10mM * 1mLin DMSO
  • 价格:220元
氯塞酮生产厂家
  • 公司名称:北京华美互利生物化工
  • 联系电话:010-56205725
  • 电子邮件:waley188@sohu.com
  • 国家:中国
  • 产品数:12338
  • 优势度:58
  • 公司名称:TargetMol中国(陶术生物)
  • 联系电话:021-33632979 15002134094
  • 电子邮件:marketing@targetmol.com
  • 国家:中国
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  • 公司名称:深圳振强生物技术有限公司
  • 联系电话:0755-66853366 15920483169
  • 电子邮件:sales@chem-strong.com
  • 国家:中国
  • 产品数:17944
  • 优势度:56
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