辅酶Q9

生物活性靶点体内研究辅酶Q9 试剂级价格

辅酶Q9

CAS号:303-97-9
英文名:COENZYME Q9
中文名:辅酶Q9
CBNumber:CB3145416
分子式:C54H82O4
分子量:795.23
MOL File:303-97-9.mol

辅酶Q9化学性质

熔点 :41-43°C
沸点 :826.8±65.0 °C(Predicted)
密度 :0.97±0.1 g/cm3(Predicted)
储存条件 :-20°C
溶解度 :Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated)
形态 :Solid
颜色 :Yellow to Orange
BRN :1900081
稳定性 :Light Sensitive

安全信息

安全说明 :22-24/25
WGK Germany :2
RTECS号 :DK4786000
F :8-10
海关编码 :29146990
毒性 :LD50 oral in rat: > 4gm/kg

辅酶Q9性质、用途与生产工艺

生物活性 Coenzyme Q9 (Ubiquinone Q9) 是啮齿类动物泛醌的主要形式，是电子传递链中的一种双亲分子组分，具有内源性抗氧化剂的作用。Coenzyme Q9 可减轻糖尿病引起的抗氧化防御机制的下降。Coenzyme Q9 改善左心室功能，减少心肌梗死面积和心肌细胞凋亡。
靶点

Human Endogenous Metabolite

体内研究

Coenzyme Q9 (5 mg/kg; p.o.; once a day for 4 weeks) reduces myocardial ischemia/reperfusion injury.
CoQ ₁₀ and CoQ ₉ are components of themitochondrial respiratory chain in mammals and can regulate some mitochondrial proteins/functions. Soybean, corn, and rapeseed oils are very rich sources of CoQ ₁₀ , whereas CoQ ₉ has been found in high concentrations in corn oil.
The lack of a functional CoQ ₉ protein in homozygous CoQ ₉ mutant (CoQ ₉ (X/X)) mice causes a severe reduction in the CoQ ₇ protein and a widespread CoQ deficiency and accumulation of demethoxyubiquinone. The deficit in CoQ induces a brain-specific impairment of mitochondrial bioenergetics performance, a reduction in respiratory control ratio, ATP levels and ATP/ADP ratio and specific loss of respiratory complex I. These effects lead to neuronal death and demyelinization with severe vacuolization and astrogliosis in the brain of CoQ ₉ (X/X) mice that consequently die between 3 and 6 months of age.

Animal Model:	Male Hartley guinea pigs of about 350-400 g body weight
Dosage:	5 mg/kg of body weight
Administration:	P.o.; once a day for 4 weeks
Result:	Nutritional supplementation of CoQ9 can reduce myocardial ischemia/reperfusion injury to the same extent as CoQ10.