昔美酸沙美特罗

生物活性靶点体外研究体内研究昔美酸沙美特罗试剂级价格

昔美酸沙美特罗

CAS号:94749-08-3
英文名:Salmeterol xinafoate
中文名:昔美酸沙美特罗
CBNumber:CB2751968
分子式:C36H45NO7
分子量:603.74
MOL File:94749-08-3.mol

昔美酸沙美特罗化学性质

熔点 :137-138°C
储存条件 :2-8°C
溶解度 :H₂O: slightly soluble
形态 :solid
颜色 :white
Merck :14,8337
InChIKey :XTZNCVSCVHTPAI-UHFFFAOYSA-N
CAS 数据库 :94749-08-3(CAS DataBase Reference)

安全信息

危险品标志 :Xi
危险类别码 :36/37/38
安全说明 :22-24/25-36-26
WGK Germany :3
RTECS号 :QJ1970500
海关编码 :2922504500

昔美酸沙美特罗化学药品说明书

苯磺阿曲库铵注射液

昔美酸沙美特罗性质、用途与生产工艺

生物活性 Salmeterol Xinafoate是一种长效的β2-adrenergic receptor激动剂，具有抗炎作用，用于哮喘症状和慢性阻塞性肺疾病（COPD）症状的治疗。
靶点
Target Value
β2-adrenergic receptor

体外研究

Salmeterol (0.001-25 µM) inhibits human T lymphocyte proliferation.

Cell Proliferation Assay

Cell Line:	Human T lymphocytes (THP-1 cells)
Concentration:	0.001, 0.01, 0.05, 0.2, 1, 5, and 25 µM
Incubation Time:
Result:	The proliferation of Th2 cells was inhibited in a concentration dependent manner.

体内研究

Salmeterol (0.16 mg/kg), Formoterol (0.32 mg/kg) and combined treatment have therapeutic effects in mice with chronic obstructive pulmonary disease (COPD).

Animal Model:	Male C57BL/6 mice (6-8 weeks old, body weight: 32-35 g)
Dosage:	Salmeterol (0.16 mg/kg) and/or Formoterol (0.32 mg/kg)
Administration:	The therapeutic efficacy of co-treatment was investigated in this model over a 56-day-long observation period.
Result:	COPD assessment test scores were markedly improved in mice with COPD.