生物活性 体外研究 异长叶烯 试剂级价格
ChemicalBook  CAS数据库列表  异长叶烯

异长叶烯

异长叶烯,1135-66-6,结构式
异长叶烯
  • CAS号:1135-66-6
  • 英文名:Isolongifolene
  • 中文名:异长叶烯
  • CBNumber:CB2415088
  • 分子式:C15H24
  • 分子量:204.35
  • MOL File:1135-66-6.mol
异长叶烯化学性质
安全信息
  • 危险类别码 :10
  • 危险品运输编号 :UN 2319 3/PG 3
  • WGK Germany :3
  • 危险等级 :3.2
  • 包装类别 :III

异长叶烯性质、用途与生产工艺

  • 生物活性 Isolongifolene ((-)-Isolongifolene) 是一种从 Murraya koenigii 中分离的三环倍半萜烯。Isolongifolene 通过调节 P13K/AKT/GSK-3β 信号通路来减轻鱼藤酮诱导的氧化应激,线粒体功能障碍和细胞凋亡。Isolongifolene 具有抗氧化,抗炎,抗癌和神经保护的特性。
  • 体外研究

    Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner.
    Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells.
    Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene.

    Cell Viability Assay

    Cell Line: SH-SY5Y neuroblastoma cells
    Concentration: 0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 µM
    Incubation Time: 26 hours
    Result: Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells.

    Apoptosis Analysis

    Cell Line: SH-SY5Y neuroblastoma cells
    Concentration: 10 µM
    Incubation Time: 26 hours
    Result: Attenuated Rotenone-induced apoptosis in SH-SY5Y cells.

    Western Blot Analysis

    Cell Line: SH-SY5Y neuroblastoma cells
    Concentration: 10 µM
    Incubation Time: 26 hours
    Result: Attenuated rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β.
  • 用途  是制造具有木香香气的合成香料异长叶烷酮和异长叶甲酸酯的主要原料
异长叶烯上下游产品信息
上游原料
下游产品
异长叶烯 试剂级价格
  • 更新日期:2024/11/08
  • 产品编号:HY-N7363
  • 产品名称:Isolongifolene
  • CAS编号:
  • 包装:1 mg
  • 价格:514元
  • 更新日期:2024/11/08
  • 产品编号:HY-N7363
  • 产品名称:异长叶烯 Isolongifolene
  • CAS编号:1135-66-6
  • 包装:5mg
  • 价格:1350元
异长叶烯生产厂家
  • 公司名称:Triveni chemicals
  • 联系电话:--
  • 电子邮件:sales@trivenichemical.com
  • 国家:印度
  • 产品数:6088
  • 优势度:58
1135-66-6, 异长叶烯相关搜索: