异长叶烯

生物活性体外研究异长叶烯试剂级价格

异长叶烯

CAS号:1135-66-6
英文名:Isolongifolene
中文名:异长叶烯
CBNumber:CB2415088
分子式:C15H24
分子量:204.35
MOL File:1135-66-6.mol

异长叶烯化学性质

沸点 :255-256 °C
密度 :0.930 g/mL at 20 °C(lit.)
蒸气压 :5.49Pa at 25℃
折射率 :n20/D 1.499
闪点 :49°C
储存条件 :2-8°C
溶解度 :DMSO: 10 mg/mL (48.94 mM)
形态 :Liquid
颜色 :Colorless to light yellow
气味 (Odor) :at 100.00 %. woody dusty amber incense
香型 :woody
旋光性 (optical activity) :[α]20/D 138±2°, c = 1% in ethanol
水溶解性 :59.998μg/L at 25℃
BRN :2207559
LogP :5.77 at 25℃
CAS 数据库 :1135-66-6(CAS DataBase Reference)
NIST化学物质信息 :2H-2,4a-methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2s)-(1135-66-6)
EPA化学物质信息 :2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S,4aR)- (1135-66-6)

安全信息

危险类别码 :10
危险品运输编号 :UN 2319 3/PG 3
WGK Germany :3
危险等级 :3.2
包装类别 :III

异长叶烯性质、用途与生产工艺

生物活性 Isolongifolene ((-)-Isolongifolene) 是一种从 Murraya koenigii 中分离的三环倍半萜烯。Isolongifolene 通过调节 P13K/AKT/GSK-3β 信号通路来减轻鱼藤酮诱导的氧化应激，线粒体功能障碍和细胞凋亡。Isolongifolene 具有抗氧化，抗炎，抗癌和神经保护的特性。

体外研究

Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner.
Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells.
Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene.

Cell Viability Assay

Cell Line:	SH-SY5Y neuroblastoma cells
Concentration:	0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 µM
Incubation Time:	26 hours
Result:	Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells.

Apoptosis Analysis

Cell Line:	SH-SY5Y neuroblastoma cells
Concentration:	10 µM
Incubation Time:	26 hours
Result:	Attenuated Rotenone-induced apoptosis in SH-SY5Y cells.

Western Blot Analysis

Cell Line:	SH-SY5Y neuroblastoma cells
Concentration:	10 µM
Incubation Time:	26 hours
Result:	Attenuated rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β.