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1135-66-6

供应商 相关产品 基本信息 物理化学性质 应用领域 安全数据 知名试剂公司产品信息 常见问题列表

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基本信息

中文
异长叶烯
英文名称
(1R)-2,2,7,7-TETRAMETHYLTRICYCLO[6.2.1.0(1.6)]UNDEC-5-ENE
(-)-ISOLONGIFOLENE
ISOLONGIFOLENE
(-)-Isolongifoline
(2s)-1,3,4,5,6,7-hexahydro-1,1,5,5
(2s)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2h-2,4a-methanonaphthalene
2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-
2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S,4aR)-(-)-
2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S-cis)-
3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-4a-methanonaphthalen(2s)-2h-1
4a-Methanonaphthalene,1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-,(2S)-2H-2
Isolongipholene
C15 H24, 2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S)-
ISOLONGIFOLENE(SG)
(2s)-2h-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-4a-methanonaphthalen
1,3,4,5,6,7-Hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene
ISOLONGIFOLENE WITH GC
(2S,4aR)-1,2,3,4,4a,5,6,7-Octahydro-1,1,5,5-tetramethyl-2,4a-methanonaphthalene
(2S,4aR)-1,3,4,5,6,7-Hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene
(2S,4aR)-1,3,4,5,6,7-Hexahydro-1,1,5,5-tetramethyl-2H-2α,4aα-methanonaphthalene
CAS
1135-66-6
中文名称
(2S)-1,3,4,5,6,7-六氢-1,1,5,5-四甲基-2H-2,4A-亚甲基萘
异长叶烯
(-)-异长叶烯
EINECS 编号
214-494-2
分子式
C15H24
MDL 编号
MFCD00042616
分子量
204.35
MOL 文件
1135-66-6.mol

物理化学性质

外观性质
微黄色液体,不溶于水,溶于乙醇等有机溶剂。沸点:113~114℃折光率:1.499密度:0.930闪点:49 °C
沸点 
255-256 °C

密度 
0.930 g/mL at 20 °C(lit.)

折射率 
n20/D 1.499

闪点 
49°C

应用领域

用途一
是制造具有木香香气的合成香料异长叶烷酮和异长叶甲酸酯的主要原料
用途二
可用于合成异长叶烷酮、环氧长叶烯和乙酰基异长叶烷酮等重要香料。

安全数据

危险类别码 
R10
危险品运输编号 
UN 2319 3/PG 3

WGK Germany 
3

危险等级
3.2
包装类别
III

知名试剂公司产品信息

常见问题列表

生物活性
Isolongifolene ((-)-Isolongifolene) 是一种从 Murraya koenigii 中分离的三环倍半萜烯。Isolongifolene 通过调节 P13K/AKT/GSK-3β 信号通路来减轻鱼藤酮诱导的氧化应激,线粒体功能障碍和细胞凋亡。Isolongifolene 具有抗氧化,抗炎,抗癌和神经保护的特性。
体外研究

Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner.
Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells.
Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene.

Cell Viability Assay

Cell Line: SH-SY5Y neuroblastoma cells
Concentration: 0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 µM
Incubation Time: 26 hours
Result: Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells.

Apoptosis Analysis

Cell Line: SH-SY5Y neuroblastoma cells
Concentration: 10 µM
Incubation Time: 26 hours
Result: Attenuated Rotenone-induced apoptosis in SH-SY5Y cells.

Western Blot Analysis

Cell Line: SH-SY5Y neuroblastoma cells
Concentration: 10 µM
Incubation Time: 26 hours
Result: Attenuated rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β.

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