新补骨脂异黄酮

新补骨脂异黄酮化学性质

熔点 :195-196℃
沸点 :545.0±50.0 °C(Predicted)
密度 :1.279
储存条件 :under inert gas (nitrogen or Argon) at 2-8°C
溶解度 :DMF: 20 mg/mL; DMF:PBS (pH 7.2) (1:4): 0.1 mg/mL; DMSO: 10 mg/mL; Ethanol: 1 mg/mL
酸度系数(pKa) :6.92±0.20(Predicted)
形态 :Yellow solid.
颜色 :White to Light yellow to Light orange
最大波长(λmax) :300nm(lit.)

安全信息

新补骨脂异黄酮性质、用途与生产工艺

生物活性 Neobavaisoflavone，是一种从 Psoralea corylifolia 的种子中分离出来的类黄酮。Neobavaisoflavone 具有抗炎，抗癌和抗氧化的作用。Neobavaisoflavone 在中至高浓度下可抑制 DNA 聚合酶 (DNA polymerase)。Neobavaisoflavone 也可抑制血小板聚集。
靶点

DNA polymerase
体外研究

Neobavaisoflavone (1-50 μM; 20 h) decreases NO (ED ₅₀ =25 μM) and cytokine (ED ₅₀ s=23.11, 5.03, 5.23, 5.26 and 18.80 μM for IL-1β, IL-6, IL-12p40, IL-12p70 and TNF-α, respectively) production in LPS plus IFN-γ-stimulated RAW264.7 macrophages.
Neobavaisoflavone (1-100 μM; 30 min) decreases the chemiluminescence in PMA-stimulated RAW264.7 macrophages, with an ED ₅₀ of 19.94 μM in activated RAW264.7 cells.
Neobavaisoflavone (1-100 μM); 20 h) has no effect on the viability and is not toxic to RAW264.7 cells.
Neobavaisoflavone (20-50 μM; 48 h) inhibits prostate cancer cell proliferation by inducing cytotoxicity and apoptosis in a dose-dependent manner.
Neobavaisoflavone (2-8 μM; 7 d) inhibits RANKL‐mediated osteoclastogenesis in bone marrow monocytes (BMMCs) and RAW264.7 cells dose dependently at the early stage.

体内研究

Neobavaisoflavone (30 mg/kg; i.p. for 6 weeks) inhibits osteoclastogenesis, promotes osteogenesis and ameliorates bone loss in ovariectomized mice.

Animal Model:	C57BL/6 female mice (8 weeksd; 20-25 g) were removed bilateral ovaries
Dosage:	30 mg/kg
Administration:	I.p. for 6 weeks
Result:	Attenuated bone loss by inhibiting osteoclast activation and promoting osteogenesis in ovariectomized mice.

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