生物活性 体内研究
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戊曲酯

戊曲酯,18296-44-1,结构式
戊曲酯
  • CAS号:18296-44-1
  • 英文名:Valtrate
  • 中文名:戊曲酯
  • CBNumber:CB1507016
  • 分子式:C22H30O8
  • 分子量:422.47
  • MOL File:18296-44-1.mol
戊曲酯化学性质
  • 沸点 :525.9±50.0 °C(Predicted)
  • 密度 :1.22±0.1 g/cm3(Predicted)
  • 储存条件 :Refrigerator
  • 溶解度 :Chloroform (Slightly, Sonicated), Methanol (Slightly)
  • 形态 :Oil
  • 颜色 :Pale Brown to Dark Yellow
  • 水溶解性 :slightly soluble in water
安全信息
  • 海关编码 :29329990

戊曲酯性质、用途与生产工艺

  • 生物活性 Valepotriate, 从 Valeriana jatamansi 分离而来,具有抗癫痫和抗癌活性。
  • 体内研究

    Valepotriate showed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50 values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore, valepotriate (10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore, valepotriate (5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB.

  • 化学性质  黄色液体,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于蛛蛛香,缬草。
  • 用途  缬草三酯具有抗肿瘤,抗老年痴呆的作用。
  • 用途  用于含量测定/鉴定/药理实验等。
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