依氟鸟氨酸盐酸盐一水合物
- CAS号:96020-91-6
- 英文名:Eflornithine hydrochloride hydrate
- 中文名:依氟鸟氨酸盐酸盐一水合物
- CBNumber:CB21261062
- 分子式:C6H15ClF2N2O3
- 分子量:236.64
- MOL File:96020-91-6.mol
- 熔点 :>210°C (dec.)
- 储存条件 :Inert atmosphere,2-8°C
- 溶解度 :Soluble in Water (up to 25 mg/ml).
- 形态 :White powder
- 颜色 :White
- Merck :14,3522
- 稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
- CAS 数据库 :96020-91-6
- RTECS号 :RM2981900
- 海关编码 :2922493800
依氟鸟氨酸盐酸盐一水合物性质、用途与生产工艺
- 生物活性 Eflornithine (Difluoromethylornithine, DFMO, MDL-71782, RMI-71782, α-difluoromethylornithine) hydrochloride hydrate 通过对鸟氨酸脱羧酶的不可逆抑制作用,抑制多胺生物合成。它是一种化疗保护剂,可阻止血管生成。其生物半衰期为8小时。
-
靶点
Target Value Orn decarboxylase -
体外研究
用α-difluoromethyl-Orn处理BY2细胞,抑制其过氧化氢的产生,但并没有发生程序性细胞死亡。
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体内研究
Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension.
- 更新日期:2024/11/08
- 产品编号:46270
- 产品名称:依氟鸟氨酸盐酸盐一水合物 Eflornithine hydrochloride monohydrate
- CAS编号:96020-91-6
- 包装:1g
- 价格:431元
- 更新日期:2024/11/08
- 产品编号:46270
- 产品名称:依氟鸟氨酸盐酸盐一水合物 Eflornithine hydrochloride monohydrate
- CAS编号:96020-91-6
- 包装:5g
- 价格:1221元
- 公司名称:TOKYO CHEMICAL INDUSTRY CO., LTD.
- 联系电话:03-36680489
- 电子邮件:Sales-JP@TCIchemicals.com
- 国家:日本
- 产品数:28387
- 优势度:80
- 公司名称:WATANABE
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- 国家:日本
- 产品数:4811
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