ChemicalBook CAS数据库列表 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone

[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone

CAS号:1360705-96-9
英文名:[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
中文名:[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
CBNumber:CB12750494
分子式:C22H20Cl2N4O4
分子量:475.32
MOL File:1360705-96-9.mol

[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone化学性质

沸点 :644.7±55.0 °C(Predicted)
密度 :1.415±0.06 g/cm3(Predicted)
储存条件 :2-8°C
溶解度 :Soluble in DMSO (up to 30 mg/ml)
酸度系数(pKa) :4.69±0.10(Predicted)
形态 :powder
颜色 :white to beige
稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

安全信息

[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone性质、用途与生产工艺

生物活性 ML-210 (CID 49766530)是一种选择性的 glutathione peroxidase 4 (GPX4) 的共价抑制剂，其EC50值为0.04 μM，可诱导铁死亡。ML-210 可以选择性地杀死诱导表达突变型 RAS 的细胞，并具有抗癌活性。
靶点
Target Value
RAS
()
GPX4
(Cell-free assay) 0.04 μM(EC50)
体外研究

ML-210 exhibits cell-killing activity across a panel of 821 cancer cell lines (WM88, LOX-IMVI, CJM, U257, CAKI2, A498, HT1080, MC38, PANC02). ML-210 is a prodrug that requires cellular activation to bind GPX4.
ML-210 has IC ₅₀ s of 71 nM, 272 nM and 107nM for BJeLR (HRAS _V12 ), BJeH-LT (without HRAS _V12 ) and DRD cell lines, respectively.

[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone上下游产品信息

上游原料

下游产品

更新日期：2024/11/08
产品编号：S0788
产品名称：[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML 210
CAS编号：1360705-96-9
包装：2mg
价格：647.01元

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