相思豆毒素
- CAS号:526-31-8
- 英文名:L-ABRINE
- 中文名:相思豆毒素
- CBNumber:CB1236662
- 分子式:C12H14N2O2
- 分子量:218.25
- MOL File:526-31-8.mol
- 熔点 :>300 °C (dec.)(lit.)
- 比旋光度 :D21 +44° (0.28 g in 10 ml 0.5N HCl)
- 沸点 :358.94°C (rough estimate)
- 密度 :1.272±0.06 g/cm3 (20 ºC 760 Torr)
- 折射率 :65 ° (C=1, 0.5mol/L NaOH)
- 储存条件 :under inert gas (nitrogen or Argon) at 2–8 °C
- 溶解度 :H2O : 2 mg/mL (9.16 mM; ultrasonic and adjust pH to 10 with NaOH)
- 形态 :Cryst.
- 酸度系数(pKa) :2.32±0.10(Predicted)
- 颜色 :Off-white to light yellow
- 旋光性 (optical activity) :[α]20/D +65°, c = 1 in 0.5 M NaOH
- Merck :14,10
- BRN :86638
- CAS 数据库 :526-31-8(CAS DataBase Reference)
相思豆毒素性质、用途与生产工艺
- 生物活性 L-Abrine (N-Methyl-L-tryptophan)是相思子根部的毒性清蛋白,可抑制核糖体。
-
体外研究
L-(+)-Abrine is a marker for abrin poisoning. A strong indication for abrin poisoning is the presence of the chemical maker L-(+)-Abrine, which can survive metabolism in significant amounts making it detectable in human urine.
-
体内研究
Abrin is a toxic protein found in the jequirity seed. L-(+)-Abrine (L-Abrine) is also found in the jequirity seed and can be used as a biomarker for abrin exposure. An animal study is designed to monitor the excretion and recovery of L-(+)-Abrine in 20 rats. The animals are exposed to one of three concentrations of L-(+)-Abrine, a single high concentration of L-tryptophan, or no agent (control). The low L-(+)-Abrine dose corresponds to 0.63 LD 50 i.p. abrin in mice, assuming a concentration ratio of 1:4 of abrin to L-(+)-Abrine and an LD 50 for abrin of 20 μg/kg. The mid and high L-(+)-Abrine (250 and 400 μg/kg) doses are included to ensure that the target analyte can be detected and tracked over the course of the experiment.
- 用途 一种在体外表现出自由基清除和抗氧化剂特性的吲哚氨基酸。
- 更新日期:2024/11/08
- 产品编号:S5828
- 产品名称:相思豆毒素 L-Abrine
- CAS编号:526-31-8
- 包装:25mg
- 价格:1204.73元
- 更新日期:2018/06/12
- 产品编号:A1489
- 产品名称:L-红豆碱 L-Abrine
- CAS编号:526-31-8
- 包装:200MG
- 价格:375元
- 公司名称:KANTO
- 联系电话:--
- 电子邮件:reag-info@gms.kanto.co.jp
- 国家:日本
- 产品数:6756
- 优势度:74