牛心果鹼
- CAS号:485-19-8
- 英文名:(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol
- 中文名:牛心果鹼
- CBNumber:CB0916990
- 分子式:C19H23NO4
- 分子量:329.39
- MOL File:485-19-8.mol
- 熔点 :125-126°C
- 沸点 :648.96°C (rough estimate)
- 密度 :1.4371 (rough estimate)
- 折射率 :1.6800 (estimate)
- 储存条件 :Sealed in dry,2-8°C
- 溶解度 :Soluble in DMSO
- 形态 :Solid
- 酸度系数(pKa) :9.95±0.10(Predicted)
- 颜色 :Off-white to yellow
- 旋光性 (optical activity) :+88.318 (c 0.21, ethanol)
牛心果鹼性质、用途与生产工艺
- 生物活性 Reticuline 分离自 Litsea cubeba，通过 JAK2/STAT3 和 NF-κB 信号通路显示抗炎作用。Reticuline 还可抑制 TNF-α 和 IL-6 的 mRNA 表达，并降低 JAK2 和 STAT3 的磷酸化水平。Reticuline 具有心血管作用。
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靶点
JAK2
STAT3
NF-κB
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体外研究
Reticuline (3 μM, 30 μM, 300 μM, 900 μM and 1.5 mM) inhibits in a concentration-dependent manner the contractions induced by Phenylephrine (1 μM), KCl (80 mM) and KCl (30 mM), (IC 50 =40±10, 240±40 and 300±40 μM, respectively) in isolated rat aortic rings with intact endothelium.
Reticuline (3 μM, 30 μM, 300 μM, 900 μM and 1.5 mM) antagonizes CaCl 2 -induced contractions, and also inhibits the intracellular calcium dependent transient contractions induced by Norepinephrine (1μM), but not those induced by Caffeine (20 mM). -
体内研究
Reticuline (5, 10 and 20 mg/kg, i. v., randomly) injections produced an intense hypotension in normotensive rats. The hypotensive effect of Reticuline is probably due to a peripheral vasodilation in consequence of: 1) muscarinic stimulation and NOS activation in the vascular endothelium, 2) voltage-dependent Ca 2+ channel blockade and/or 3) inhibition of Ca 2+ release from norepinephrine-sensitive intracellular stores.
- 化学性质 白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于印防己，山胡椒，凹叶厚朴。
- 用途 瑞枯灵具有抗血小板聚集，抑制子宫平滑肌收缩的作用。
- 更新日期：2024/11/08
- 产品编号：HY-N1356
- 产品名称：牛心果鹼 Reticuline
- CAS编号：485-19-8
- 包装：1mg
- 价格：2000元
- 更新日期：2024/11/08
- 产品编号：HY-N1356
- 产品名称：牛心果鹼 Reticuline
- CAS编号：485-19-8
- 包装：5mg
- 价格：4600元
- 公司名称：Carbosynth
- 联系电话：--
- 电子邮件：sales@carbosynth.com
- 国家：英国
- 产品数：6005
- 优势度：58
