内消旋-四(4 - 羧基苯基)卟啉氯化锰(Ⅲ)

内消旋-四(4 - 羧基苯基)卟啉氯化锰(Ⅲ)化学性质

储存条件 :-20C
溶解度 :Soluble in 0.1M NaOH
形态 :Brown solid
颜色 :Black
稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in 0.1M NaOH may be stored at -20° for up to 1 month.

内消旋-四(4 - 羧基苯基)卟啉氯化锰(Ⅲ)性质、用途与生产工艺

简介 MnTBAP (55266-18-7) 是一种超氧化物歧化酶 (SOD) 模拟物，可用作过氧亚硝酸盐清除剂，但不清除一氧化氮。
生物活性 MnTBAP chloride 是一种超氧化物歧化酶 (SOD) 模拟物和过氧亚硝酸盐清除剂。MnTBAP chloride 是一种锰卟啉配合物，具有抗氧化性能。MnTBAP chloride 通过上调 BMPR-II 和抑制 NFκB 信号传导介导抗炎作用。MnTBAP chloride 具有抗氧化性能，具有用于研究慢性肾脏疾病 (CKDs) 纤维化反应的潜力。
靶点

NFκB
体外研究

MnTBAP chloride (pretreated 1.14 μM before TGF-β1 of 10 ng/mL) partially but significantly restores E-cadherin reduction and suppresses the induction of α-SMA and vimentin in immortalized mouse proximal tubular cells (mPTCs).
MnTBAP chloride (50 μM; 6 hours) increases BMPR-II mRNA by 1.3-fold at 2 h, but does not affect protein expression of BMPR-II during a time course of 16 h in HUVECs. MnTBAP chloride increases phosphorylation of Smad 1/5, suggesting modulation of the BMP signaling pathway.

体内研究

MnTBAP chloride (10 mg/kg; IP; three times per week for twelve weeks) attenuates renal fibrosis in 5/6 Nx mice.

Animal Model:	C57BL/6J mice with 5/6 nephrectomy (Nx)
Dosage:	10 mg/kg
Administration:	IP; three times per week for twelve weeks
Result:	Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys.

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