生物活性 靶点 体外研究 体内研究 4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐 试剂级价格
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4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐

4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐,182563-08-2,结构式
4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐
  • CAS号:182563-08-2
  • 英文名:LY 334370 HYDROCHLORIDE
  • 中文名:4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐
  • CBNumber:CB02459701
  • 分子式:C21H22FN3O
  • 分子量:351.42
  • MOL File:182563-08-2.mol
4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐化学性质
  • 沸点 :479.1±45.0 °C(Predicted)
  • 密度 :1.267±0.06 g/cm3(Predicted)
  • 储存条件 :Store at +4°C
  • 溶解度 :H2O: ≥5mg/mL (warmed)
  • 形态 :powder
  • 酸度系数(pKa) :13.98±0.43(Predicted)
  • 颜色 :white to tan
安全信息
  • WGK Germany :3

4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐性质、用途与生产工艺

  • 生物活性 LY334370 是一个选择性的 5-HT1F 受体激动剂,其 Ki 值为 1.6 nM。
  • 靶点

    5-HT 1F Receptor

    1.6 nM (Ki)

  • 体外研究

    LY334370 has no vasoconstrictor effects on human cerebral arteries in vitro until a dose of 10 -5 M, at which it produces a contraction of 8.5±5.7%; however, this is not significant.

  • 体内研究

    Following intravenous administration of LY334370 at 3 mg/kg (n=3) or 10 mg/kg (n=6) electrical stimulation evokes an increase in dural blood vessel diameter of 135±6% and 106±11%, respectively, which is not significantly different from the respective control values. LY334370 has no effect on dural blood vessel diameter per se , since the actual dural blood vessel diameter is 43±4 arbitrary units before drug and 43±4 arbitrary units 15 min after injection of LY334370 (10 mg/kg).

4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐上下游产品信息
上游原料
下游产品
4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐 试剂级价格
  • 更新日期:2024/08/19
  • 产品编号:HY-103107
  • 产品名称:4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐 LY334370
  • CAS编号:182563-08-2
  • 包装:5mg
  • 价格:800元
  • 更新日期:2024/08/19
  • 产品编号:HY-103107
  • 产品名称:4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐 LY334370
  • CAS编号:182563-08-2
  • 包装:10mM * 1mLin DMSO
  • 价格:880元
4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐生产厂家
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