生物活性 体外研究 体内研究 N-[2-[[[4-(2,2-二甲基-1-氧代丙氧基)苯基]磺酰]氨基]苯甲酰]-(S)-甘氨酸单钠盐 试剂级价格
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ChemicalBook  CAS数据库列表  N-[2-[[[4-(2,2-二甲基-1-氧代丙氧基)苯基]磺酰]氨基]苯甲酰]-(S)-甘氨酸单钠盐

N-[2-[[[4-(2,2-二甲基-1-氧代丙氧基)苯基]磺酰]氨基]苯甲酰]-(S)-甘氨酸单钠盐

生物活性 体外研究 体内研究 N-[2-[[[4-(2,2-二甲基-1-氧代丙氧基)苯基]磺酰]氨基]苯甲酰]-(S)-甘氨酸单钠盐 试剂级价格
N-[2-[[[4-(2,2-二甲基-1-氧代丙氧基)苯基]磺酰]氨基]苯甲酰]-(S)-甘氨酸单钠盐,150374-95-1,结构式
N-[2-[[[4-(2,2-二甲基-1-氧代丙氧基)苯基]磺酰]氨基]苯甲酰]-(S)-甘氨酸单钠盐
  • CAS号:150374-95-1
  • 英文名:N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt
  • 中文名:N-[2-[[[4-(2,2-二甲基-1-氧代丙氧基)苯基]磺酰]氨基]苯甲酰]-(S)-甘氨酸单钠盐
  • CBNumber:CB02131171
  • 分子式:C20H21N2NaO7S
  • 分子量:456.44
  • MOL File:150374-95-1.mol
N-[2-[[[4-(2,2-二甲基-1-氧代丙氧基)苯基]磺酰]氨基]苯甲酰]-(S)-甘氨酸单钠盐化学性质
  • 熔点 :104-108 °C(Solv: water (7732-18-5))
  • 储存条件 :Desiccate at RT
  • 溶解度 :DMSO (Slightly), Methanol (Slightly)
  • 形态 :Solid
  • 颜色 :White to Off-White

N-[2-[[[4-(2,2-二甲基-1-氧代丙氧基)苯基]磺酰]氨基]苯甲酰]-(S)-甘氨酸单钠盐性质、用途与生产工艺

  • 生物活性 Sivelestat (EI546) sodium 是竞争性的人类中性粒细胞弹性蛋白酶的抑制剂，其IC50 值为 44 nM， Ki 值为 200 nM。Sivelestat (EI546) sodium 有潜力用于COVID-19 的急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的研究。
  • 体外研究

    Sivelestat (ONO-5046) does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM.
    Sivelestat (ONO-5046) exhibits IC 50 values of 44 nM, 36 nM, 19 nM, 37 nM and 49 nM for human, rabbit, rat, hamster and mouse neutrophil elastase, respectively.

  • 体内研究

    Sivelestat (ONO-5046, 0.021-2.1 mg/kg, intratracheally) suppresses lung hemorrhage in hamster (ID 50 = 82 pg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID 50 = 9.6 mg/kg) by intravenous administration, both of which are induced by human neutrophil elastase.
    Sivelestat (10 mg/kg, infusion via the tail vein) ameliorates lung injury after hemorrhagic shock in rats.
    Sivelestat (15, 60 mg/kg, ip) prevents ischemia–reperfusion injury in the rat bladder.

    Animal Model: Male Golden hamsters, weighing 90 to 110 g.
    Dosage: 0.021-2.1 mg/kg.
    Administration: Intratracheally five min before HNE injection.
    Result: Significantly and dosedependently suppressed the lung hemorrhage.
    Animal Model: Male Sprague-Dawley rats weighing 350-400 g.
    Dosage: 10 mg/kg.
    Administration: Continuous infusion via the tail vein at 10 mg/kg/h for 60 min during the resuscitation phase.
    Result: Greatly suppressed lung injury, as revealed by the reduced histological damage.
    Significantly ameliorated HSR-induced lung injury.
    Markedly decreased the levels of TNF-α and iNOS gene.
    Animal Model: Male Sprague Dawley rats, 8 weeks old and weighing 250-320 g.
    Dosage: 15 mg/kg or 60 mg/kg.
    Administration: IP.
    Result: Decreased the blood flow in the bladder during reperfusion phase compared to the IR group.
N-[2-[[[4-(2,2-二甲基-1-氧代丙氧基)苯基]磺酰]氨基]苯甲酰]-(S)-甘氨酸单钠盐上下游产品信息
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N-[2-[[[4-(2,2-二甲基-1-氧代丙氧基)苯基]磺酰]氨基]苯甲酰]-(S)-甘氨酸单钠盐 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：HY-17443A
  • 产品名称：Sivelestat sodium
  • CAS编号：
  • 包装：5 mg
  • 价格：437元
  • 更新日期：2024/11/08
  • 产品编号：HY-17443A
  • 产品名称：N-[2-[[[4-(2,2-二甲基-1-氧代丙氧基)苯基]磺酰]氨基]苯甲酰]-(S)-甘氨酸单钠盐 Sivelestat sodium
  • CAS编号：150374-95-1
  • 包装：10mg
  • 价格：700元
N-[2-[[[4-(2,2-二甲基-1-氧代丙氧基)苯基]磺酰]氨基]苯甲酰]-(S)-甘氨酸单钠盐生产厂家
  • 公司名称：TOCRIS-US
  • 联系电话：--
  • 电子邮件：customerservice@tocris.co.uk
  • 国家：英国
  • 产品数：5726
  • 优势度：77
150374-95-1, N-[2-[[[4-(2,2-二甲基-1-氧代丙氧基)苯基]磺酰]氨基]苯甲酰]-(S)-甘氨酸单钠盐相关搜索:
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