磺丁基-Β-环糊精钠盐
- CAS号:182410-00-0
- 英文名:Betadex Sulfobutyl Ether Sodium
- 中文名:磺丁基-Β-环糊精钠盐
- CBNumber:CB00130231
- 分子式:C42H70O35
- 分子量:1134.9842
- MOL File:182410-00-0.mol
- 熔点 :202-204°C (dec.)
- 储存条件 :Inert atmosphere,Room Temperature
- 溶解度 :Soluble in water. Insoluble in acetone, methanol, chloroform.
- 形态 :Solid powder
- 颜色 :White to off white
- InChIKey :WHGYBXFWUBPSRW-CQFZCEJCNA-N
- 海关编码 :2940006000
磺丁基-Β-环糊精钠盐性质、用途与生产工艺
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用途
磺丁基醚-β-环糊精钠,是一种新型药物制剂辅料,属于阴离子型高水溶性环糊精的一种磺酸基衍生物。它能很好地与药物分子包合形成非共价复合物,提高了药物的稳定性、水溶性、安全性并且有效的提高了药物分子的生物活性它的肾毒性小,能缓和药物溶血性,控制药物释放速率。
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制备
以β-环糊精和1,4-磺丁内酯为原料,通过向碱性水溶液中引入适量有机溶剂,增加了1,4-磺丁内酯的溶解度,提高了磺丁基醚-β-环糊精的合成收率;所得产品溶液经过超声透析,活性炭脱色,冷冻干燥等操作得到磺丁基醚-β-环糊精粉末产品。
- 生物活性 Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) 是一种新型的、化学修饰过的环糊精,具有比较好的稳定性和溶解性。
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体外研究
SBE-β-CD is a chemically modified β-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media. β-CD functioned is a solubilizer only at low concentrations, whereas SBE7-β-CD exhibits strong solubilizing effects over a wide concentration range.
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体内研究
20% SBE-β-CD in saline:
Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Dissolve 0.9 g of NaCl in 100 mL distilled water to make a clear 0.9% saline solution.
2. Measure 2 g of dry SBE-β-CD.
3. Dissolve 2 g of SBE-β-CD in 0.9% saline to make 10 mL with a 20% (w/v) concentration. These may require ultrasonic (20-40 kHz, 30 seconds, repeat 3 times) or heating (37°C for about 30 minutes). If precipitation is observed, the precipitates can be dissolved by heating to 37°C and vortexing before use.
- 更新日期:2024/11/08
- 产品编号:46336
- 产品名称:磺丁基-β-环糊精钠盐 Sodium sulfobutyl ether beta-cyclodextrin, Thermo Scientific Chemicals
- CAS编号:182410-00-0
- 包装:5g
- 价格:686元
- 更新日期:2024/11/08
- 产品编号:46336
- 产品名称:磺丁基-β-环糊精钠盐 Sodium sulfobutyl ether beta-cyclodextrin, Thermo Scientific Chemicals
- CAS编号:182410-00-0
- 包装:25g
- 价格:1306元
- 公司名称:Toronto Research Chemicals Inc.
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- 国家:加拿大
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- 公司名称:TORONTO
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