磺丁基-Β-环糊精钠

用途制备生物活性体外研究体内研究磺丁基-Β-环糊精钠试剂级价格

磺丁基-Β-环糊精钠

CAS号:182410-00-0
英文名:Betadex Sulfobutyl Ether Sodium
中文名:磺丁基-Β-环糊精钠
CBNumber:CB41208906
分子式:C42H70O35
分子量:1134.9842
MOL File:182410-00-0.mol

磺丁基-Β-环糊精钠化学性质

熔点 :202-204°C (dec.)
储存条件 :Inert atmosphere,Room Temperature
溶解度 :Soluble in water. Insoluble in acetone, methanol, chloroform.
形态 :Solid powder
颜色 :White to off white
InChIKey :WHGYBXFWUBPSRW-CQFZCEJCNA-N

安全信息

海关编码 :2940006000

磺丁基-Β-环糊精钠性质、用途与生产工艺

用途
磺丁基醚-β-环糊精钠，是一种新型药物制剂辅料，属于阴离子型高水溶性环糊精的一种磺酸基衍生物。它能很好地与药物分子包合形成非共价复合物，提高了药物的稳定性、水溶性、安全性并且有效的提高了药物分子的生物活性它的肾毒性小，能缓和药物溶血性，控制药物释放速率。
制备
以β-环糊精和1,4-磺丁内酯为原料，通过向碱性水溶液中引入适量有机溶剂，增加了1,4-磺丁内酯的溶解度，提高了磺丁基醚-β-环糊精的合成收率；所得产品溶液经过超声透析，活性炭脱色，冷冻干燥等操作得到磺丁基醚-β-环糊精粉末产品。
生物活性 Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) 是一种新型的、化学修饰过的环糊精，具有比较好的稳定性和溶解性。
体外研究

SBE-β-CD is a chemically modified β-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media. β-CD functioned is a solubilizer only at low concentrations, whereas SBE7-β-CD exhibits strong solubilizing effects over a wide concentration range.
体内研究

20% SBE-β-CD in saline:
Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Dissolve 0.9 g of NaCl in 100 mL distilled water to make a clear 0.9% saline solution.
2. Measure 2 g of dry SBE-β-CD.
3. Dissolve 2 g of SBE-β-CD in 0.9% saline to make 10 mL with a 20% (w/v) concentration. These may require ultrasonic (20-40 kHz, 30 seconds, repeat 3 times) or heating (37°C for about 30 minutes). If precipitation is observed, the precipitates can be dissolved by heating to 37°C and vortexing before use.