磺丁基倍他环糊精钠

用途制备生物活性体外研究体内研究磺丁基倍他环糊精钠试剂级价格

磺丁基倍他环糊精钠

CAS号:182410-00-0
英文名:Betadex Sulfobutyl Ether Sodium
中文名:磺丁基倍他环糊精钠
CBNumber:CB00125166
分子式:C42H70O35
分子量:1134.9842
MOL File:182410-00-0.mol

磺丁基倍他环糊精钠化学性质

熔点 :202-204°C (dec.)
储存条件 :Inert atmosphere,Room Temperature
溶解度 :Soluble in water. Insoluble in acetone, methanol, chloroform.
形态 :Solid powder
颜色 :White to off white
InChIKey :WHGYBXFWUBPSRW-CQFZCEJCNA-N

安全信息

海关编码 :2940006000

磺丁基倍他环糊精钠性质、用途与生产工艺

用途
磺丁基醚-β-环糊精钠，是一种新型药物制剂辅料，属于阴离子型高水溶性环糊精的一种磺酸基衍生物。它能很好地与药物分子包合形成非共价复合物，提高了药物的稳定性、水溶性、安全性并且有效的提高了药物分子的生物活性它的肾毒性小，能缓和药物溶血性，控制药物释放速率。
制备
以β-环糊精和1,4-磺丁内酯为原料，通过向碱性水溶液中引入适量有机溶剂，增加了1,4-磺丁内酯的溶解度，提高了磺丁基醚-β-环糊精的合成收率；所得产品溶液经过超声透析，活性炭脱色，冷冻干燥等操作得到磺丁基醚-β-环糊精粉末产品。
生物活性 Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) 是一种新型的、化学修饰过的环糊精，具有比较好的稳定性和溶解性。
体外研究

SBE-β-CD is a chemically modified β-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media. β-CD functioned is a solubilizer only at low concentrations, whereas SBE7-β-CD exhibits strong solubilizing effects over a wide concentration range.
体内研究

20% SBE-β-CD in saline:
Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Dissolve 0.9 g of NaCl in 100 mL distilled water to make a clear 0.9% saline solution.
2. Measure 2 g of dry SBE-β-CD.
3. Dissolve 2 g of SBE-β-CD in 0.9% saline to make 10 mL with a 20% (w/v) concentration. These may require ultrasonic (20-40 kHz, 30 seconds, repeat 3 times) or heating (37°C for about 30 minutes). If precipitation is observed, the precipitates can be dissolved by heating to 37°C and vortexing before use.