92-78-4
基本信息
冰染偶合组分 10
色酚 AS-E
2-羟基-N-(4氯基苯基)-3-萘甲酰胺
纳夫妥AS-E
萘酚AS-E
色酚AS-E
C.I.冰染偶合组分10
AZOIC COUPLING COMPONENT 10
c.i. azoic coupling component 10
N-(4-CHLOROPHENYL)-3-HYDROXY-2-NAPHTHAMIDE
NAPHTHOL AS-E
NAPTHOL AS-E
AcnaNaphtholPC
DaitoGrounderE
n-(4-chlorophenyl)-3-hydroxy-2-naphthalenecarboxamid
2-Hydroxy-3-Naphthoyl-p-Chloraniline
2-Naphthalenecarboxamide-N-(4-chlorophenyl)-3-hydroxy
4′-Chlor-3-hydroxy-2-naphthanilid
Naphthol AS-E (C.I. 37510)
4''-CHLORO-3-HYDROXY-2-NAPHTHANILIDE 97.0+%(T)
C.I. 37510
Amarthol AS-E
Kiwa Grounder E
Naftol AS-E
N-(4-Chlorophenyl)-3-hydroxynaphthalene-2-carboxamide
物理化学性质
| 外观性状 | 浅米色粉末。 溶于邻二氯苯。溶于烧碱溶液中呈黄色。不溶于水和纯碱溶液。 |
| 溶解性 | 溶于邻二氯苯。溶于烧碱溶液中呈黄色。不溶于水和纯碱溶液。 |
| 熔点 | 255°C |
| 沸点 | 416.5±30.0 °C(Predicted) |
| 密度 | 1.399±0.06 g/cm3(Predicted) |
| 蒸气压 | 0Pa at 25℃ |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 溶于二甲基甲酰胺 |
| 色指数 | 37510 |
| 酸度系数(pKa) | 8.69±0.40(Predicted) |
| 形态 | 米色固体 |
| 颜色 | 白色至淡黄色至深绿色 |
| LogP | 2.97 at 23℃ and pH7.2 |
| CAS 数据库 | 92-78-4(CAS DataBase Reference) |
| EPA化学物质信息 | 2-Naphthalenecarboxamide, N-(4-chlorophenyl)-3-hydroxy- (92-78-4) |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H317-H319 |
| 防范说明 | P261-P264-P272-P280-P302+P352-P305+P351+P338 |
| TSCA | TSCA listed |
| REACH 注册登记 | Active |
| 海关编码 | 2924.29.7790 |
应用领域
制备方法
图谱信息
色酚 AS-E(92-78-4)质谱(MS)色酚 AS-E(92-78-4)核磁图(1HNMR)色酚 AS-E(92-78-4)核磁图(13CNMR)色酚 AS-E(92-78-4)红外图谱(IR1)色酚 AS-E(92-78-4)红外图谱(IR2)知名试剂公司产品信息
色酚 AS-E价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-104068 | 色酚 AS-E Naphthol AS-E | 92-78-4 | 50 mg | 225元 |
| 2026/09/15 | HY-104068 | 色酚 AS-E Naphthol AS-E | 92-78-4 | 10mM * 1mLin DMSO | 247元 |
| 2026/09/15 | HY-104068 | 色酚 AS-E Naphthol AS-E | 92-78-4 | 100mg | 360元 |
常见问题列表
|
KIX-KID 2.26 μM (IC 50 ) |
CREB (cyclic AMP-response element-binding protein) is a downstream transcription factor of a multitude of signaling pathways emanating from receptor tyrosine kinases or G-protein coupled receptors.CREB can not be activated until it is phosphorylated at Ser133 and its subsequent binding to CREB-binding protein (CBP) through the kinase-inducible domain (KID) in CREB and KID-interacting (KIX) domain in CBP.In a cell-based CREB Renilla luciferase reporter assay, Naphthol AS-E inhibits CREB-mediated gene transcription with an IC 50 of 2.29 µM. In HEK293T-based complementation assay, Naphthol AS-E dose-dependently inhibited Renilla luciferase activity with an IC 50 of 2.9 µM by directly binding to CBP's KIX domain (K d ~8.6 µM using a recombinant KIX).Naphthol AS-E exhibits low µM activity in inhibiting the proliferation of all these cancer cells, which is consistent with its cellular CREB inhibition potency. The average GI 50 values for A549, MCF-7, MDA-MB-231 and MDA-MB-468 are approximately 2.9µM, 2.81µM, 2.35µM and 1.46µM, respectively.Naphthol AS-E (2.5 µM-10 µM; 48 hours) decreases the expression of anti-apoptotic protein Bcl-2. The expression of VEGF is also decreased.