864082-48-4
中文名称
化合物 T27479
英文名称
GSK466317A
CAS
864082-48-4
分子式
C21H16ClF3N4O2
分子量
448.83
MOL 文件
864082-48-4.mol
结构式
物理化学性质
| 沸点 | 713.4±60.0 °C(Predicted) |
| 密度 | 1.485±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 11.54±0.40(Predicted) |
应用领域
用途一
GSK466317A is a GRK2 inhibitor. GRK2 has been directly implicated in the progression of heart failure. Selective inhibitors of individual subfamilies of G protein-coupled receptor kinases (GRKs) would serve as useful chemical probes as well as leads for therapeutic applications ranging from heart failure to Parkinson's disease.